PRDM16, LRP1 and TRPM8 genetic polymorphisms are risk factor for Pakistani migraine patients.
Association
GWAS
Migraine
Pakistani population
Susceptibility
Variants
Journal
Saudi journal of biological sciences
ISSN: 1319-562X
Titre abrégé: Saudi J Biol Sci
Pays: Saudi Arabia
ID NLM: 101543796
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
21
02
2021
revised:
08
06
2021
accepted:
09
06
2021
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
Migraine is a chronic neurovascular condition characterized by recurring attacks of pulsating headaches. Genome-wide association studies (GWAS) identified many potential loci associated with migraine. To check the association of polymorphisms of The study included 127 migraine patients (21 in migraine with aura and 106 with migraine without aura group) and 120 healthy control subjects from different areas of Punjab, Pakistan. Blood samples were collected from all the participants, and DNA was isolated from the lymphocytes by the modified organic method. Sanger's sequencing was done for We found statistically significant differences between case and control group for In this first-ever replication report from Pakistan,
Sections du résumé
BACKGROUND
BACKGROUND
Migraine is a chronic neurovascular condition characterized by recurring attacks of pulsating headaches. Genome-wide association studies (GWAS) identified many potential loci associated with migraine. To check the association of polymorphisms of
METHODS
METHODS
The study included 127 migraine patients (21 in migraine with aura and 106 with migraine without aura group) and 120 healthy control subjects from different areas of Punjab, Pakistan. Blood samples were collected from all the participants, and DNA was isolated from the lymphocytes by the modified organic method. Sanger's sequencing was done for
RESULTS
RESULTS
We found statistically significant differences between case and control group for
CONCLUSION
CONCLUSIONS
In this first-ever replication report from Pakistan,
Identifiants
pubmed: 34588893
doi: 10.1016/j.sjbs.2021.06.028
pii: S1319-562X(21)00488-5
pmc: PMC8459056
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5793-5799Informations de copyright
© 2021 The Authors.
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