Liver Abscesses as a Sign of Chronic Granulomatous Disease in Adolescent.
chronic granulomatous disease
liver abscess
nadph oxidase deficiency
primary immunodeficiency disorder
x-linked genetic diseases
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
25
08
2021
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disease caused by a genetic defect in the nicotinamide adenine dinucleotide phosphate oxidase (NADPH) complex that affects phagocytes. This leads to recurrent severe bacterial and fungal infections manifested by recurrent pneumonia, also involving soft tissue, bones, and liver. Usually, CGD is presented and diagnosed in the first five years of life. In this case report, we describe a late presentation in an adolescent with multiple liver abscesses, the approach of diagnosis, and management.
Identifiants
pubmed: 34589361
doi: 10.7759/cureus.17467
pmc: PMC8464347
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e17467Informations de copyright
Copyright © 2021, Al Ghadeer et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
N Engl J Med. 2010 Dec 30;363(27):2600-10
pubmed: 21190454
Blood Cells Mol Dis. 2010 Oct 15;45(3):246-65
pubmed: 20729109
Genes Dis. 2019 Jul 27;7(1):84-92
pubmed: 32181279
Br Med Bull. 2016 Jun;118(1):50-63
pubmed: 26983962
Pediatr Dev Pathol. 2018 Jul-Aug;21(4):347-354
pubmed: 29050515
Pediatric Health Med Ther. 2020 Jul 22;11:257-268
pubmed: 32801991
Adv Ther. 2017 Dec;34(12):2543-2557
pubmed: 29168144
PLoS One. 2009;4(4):e5234
pubmed: 19381301
Free Radic Biol Med. 2012 Jul 1;53(1):72-80
pubmed: 22583699
J Pediatric Infect Dis Soc. 2018 May 9;7(suppl_1):S2-S5
pubmed: 29746675
Harefuah. 2016 Mar;155(3):170-6, 195
pubmed: 27305752
Clin Rev Allergy Immunol. 2010 Feb;38(1):3-10
pubmed: 19504359
Biol Blood Marrow Transplant. 2012 Sep;18(9):1368-77
pubmed: 22326631
Expert Rev Clin Immunol. 2013 Feb;9(2):153-60
pubmed: 23390946
Nat Commun. 2018 Oct 25;9(1):4447
pubmed: 30361506