Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression.
Antitumor peptide
FP, fluorescence polarization
ITC, isothermal titration calorimetry
MDM2
MDM2, murine double minute 2
MDMX
MDMX, murine double minute X
P53
PMI, P53‒MDM2/MDMX inhibitor
SAR, structure‒activity relationship
SPR, surface plasmon resonance
Systematic mutational analysis
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
08
02
2021
revised:
28
05
2021
accepted:
03
06
2021
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53
Identifiants
pubmed: 34589387
doi: 10.1016/j.apsb.2021.06.010
pii: S2211-3835(21)00222-7
pmc: PMC8463443
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2655-2669Informations de copyright
© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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