Stress-buffering effect of social support on immunity and infectious risk during chemotherapy for breast cancer.
Cancer
Infectious diseases
Psychoneuroimmunology
Social factors influencing health
Social support
Stress and health
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
25
09
2020
revised:
01
12
2020
accepted:
03
12
2020
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
This study investigated the stress-buffering effect of social support on immune function and infectious risk in women with breast cancer, during and after chemotherapy. Data were collected from 50 women with breast cancer before and after their chemotherapy, as well as three months later. Stress was measured by daily hassles related to cancer and social support by marital status (MS) and perceived support from friends (Ps-fr). Blood was collected to measure innate immune markers (i.e., T cells, NK cells and neutrophils). Infections were evaluated using a semi-structured interview. Moderation, mediation and moderated mediation models were computed to test the hypotheses. Higher stress at baseline was found to significantly predict a higher occurrence of infections during chemotherapy, but not three months later. The relationship between stress and infections was not significantly explained by any of the immune markers. The interaction between stress and social support was tested using MS alone and combined with Ps-fr. A protective effect of social support on the deleterious effect of stress on infectious risk was found. Single patients reporting lower Ps-fr showed the strongest association between stress and infections, while the weakest association was found in patients in a committed relationship with a higher level of Ps-fr. Women experiencing more stress before the beginning of chemotherapy would appear to be at a higher risk of developing infections during their treatment. Results of this study also suggest that this effect could be buffered by the presence of a romantic partner and by higher Ps-fr.
Identifiants
pubmed: 34589722
doi: 10.1016/j.bbih.2020.100186
pii: S2666-3546(20)30151-4
pmc: PMC8474492
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100186Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
None.
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