Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation.
Brain
Inflammation
Lipopolysaccharide
Microdialysis
Proton gradient
Transporter
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
03
08
2020
revised:
30
09
2020
accepted:
03
12
2020
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
Uptake transporters in brain microvascular endothelial cells (BMECs) are involved in the penetration of basic (cationic) drugs such as diphenhydramine (DPHM) into the brain. Lipopolysaccharide (LPS)-induced inflammation alters the expression levels and activities of uptake transporters, which change the penetration of DPHM into the brain. A brain microdialysis study showed that the unbound brain-to-plasma partition coefficient (
Identifiants
pubmed: 34589723
doi: 10.1016/j.bbih.2020.100188
pii: S2666-3546(20)30153-8
pmc: PMC8474606
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100188Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
None.
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