T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain.
CD27
Chronic pain
Diabetic neuropathy
FlowSOM
Immunophenotyping
MAPKAPK2
MK2
Mass cytometry
SPADE
Type 1 diabetes
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
05
04
2021
revised:
31
05
2021
accepted:
04
06
2021
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
Diabetic neuropathic pain is a common and devastating complication of type 1 diabetes, but the mechanism by which it develops and persists is yet to be fully elucidated. This study utilised high-dimensional suspension mass cytometry in a pilot cohort to investigate differences in peripheral blood immunophenotypes between type 1 diabetes patients with (n = 9) and without (n = 9) peripheral neuropathic pain. The abundance and activation of several leukocyte subsets were investigated with unsupervised clustering approaches FlowSOM and SPADE, as well as by manual gating. Major findings included a proportional increase in CD4
Identifiants
pubmed: 34589782
doi: 10.1016/j.bbih.2021.100283
pii: S2666-3546(21)00086-7
pmc: PMC8474166
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100283Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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