IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS.
Autoantibodies
Chronic fatigue syndrome
IgG
Myalgic encephalomyelitis
β2 adrenergic receptor
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
08
01
2020
accepted:
03
02
2020
entrez:
30
9
2021
pubmed:
5
2
2020
medline:
5
2
2020
Statut:
epublish
Résumé
There is emerging evidence of a network of natural autoantibodies against GPCR which is dysregulated in various diseases. β2 adrenergic and M3 and M4 cholinergic receptor (β2 AdR and M3/4 mAChR) antibodies were found to be elevated in a subset of ME/CFS patients. We comparatively analyzed the effects of polyclonal IgG on β2 AdR signaling and immune cell function We found that IgGs from HC could stimulate β-arrestin recruitment and cAMP production in β2 AdR reporter cell lines whereas IgGs from CFS AAB We provide evidence that IgG can activate β2 AdR. The β2 AdR activation by IgG is attenuated in ME/CFS patients. A dysregulation of β2 AdR function could explain many symptoms of ME/CFS.
Sections du résumé
BACKGROUND
BACKGROUND
There is emerging evidence of a network of natural autoantibodies against GPCR which is dysregulated in various diseases. β2 adrenergic and M3 and M4 cholinergic receptor (β2 AdR and M3/4 mAChR) antibodies were found to be elevated in a subset of ME/CFS patients.
METHODS
METHODS
We comparatively analyzed the effects of polyclonal IgG on β2 AdR signaling and immune cell function
RESULTS
RESULTS
We found that IgGs from HC could stimulate β-arrestin recruitment and cAMP production in β2 AdR reporter cell lines whereas IgGs from CFS AAB
CONCLUSIONS
CONCLUSIONS
We provide evidence that IgG can activate β2 AdR. The β2 AdR activation by IgG is attenuated in ME/CFS patients. A dysregulation of β2 AdR function could explain many symptoms of ME/CFS.
Identifiants
pubmed: 34589837
doi: 10.1016/j.bbih.2020.100047
pii: S2666-3546(20)30012-0
pmc: PMC8474590
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100047Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
CellTrend GmbH holds a patent on the use of β adrenergic receptor antibodies in diagnosis of ME/CFS.
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