Immune activity at birth and later psychopathology in childhood.
Behavior
Cytokines
Inflammation
Mother-child cohort
Neurodevelopment
Psychopathology
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
10
07
2020
revised:
27
08
2020
accepted:
01
09
2020
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
Disruption of neurodevelopmental trajectories can alter brain circuitry and increase the risk of psychopathology later in life. While preclinical studies have demonstrated that the immune system and cytokines influence neurodevelopment, whether immune activity and in particular which cytokines at birth are associated with psychopathology remains poorly explored in children. We used data and biological samples from 869 mother-child pairs participating in the French mother-child cohort EDEN. As proxies for immune activity at birth, we measured the levels of 27 cytokines in umbilical cord blood sera (CBS). We then explored the association between CBS cytokine levels and five psychopathological dimensions assessed in 5-year-old children using the Strengths and Difficulties Questionnaire (SDQ). Five cytokines were positively associated with psychopathology: C-X-C motif chemokine Ligand (CXCL)10, interleukin (IL)-10 and IL-12p40 with emotional symptoms, C-C motif chemokine Ligand (CCL)11 with conduct problems, and CCL11, and IL-17A with peer relationships problems. In contrast, seven cytokines were negatively associated with psychopathology: IL-7, IL-15 and Tumor Necrosis Factor (TNF)-β with emotional symptoms, CCL4 and IL-6 with conduct problems, CCL26 and IL-15 with peer relationships problems, and CCL26, IL-7, IL-15, and TNF-α with abnormal prosocial behavior. Without implying causation, these associations support the notion that cytokines influence neurodevelopment in humans and the risk of psychopathology later in life.
Identifiants
pubmed: 34589885
doi: 10.1016/j.bbih.2020.100141
pii: S2666-3546(20)30106-X
pmc: PMC8474670
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100141Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
None.
Références
Front Immunol. 2019 Jul 23;10:1658
pubmed: 31428082
Neuropsychol Rev. 2010 Dec;20(4):327-48
pubmed: 21042938
Dialogues Clin Neurosci. 2012 Mar;14(1):29-37
pubmed: 22577302
Eur Psychiatry. 2015 Jul;30(5):562-8
pubmed: 25843027
Biol Psychiatry. 2006 May 1;59(9):775-85
pubmed: 16458261
Schizophr Bull. 2014 Nov;40(6):1518-25
pubmed: 24366719
Int J Dev Neurosci. 2006 Feb;24(1):73-80
pubmed: 16289943
Science. 2016 Feb 26;351(6276):933-9
pubmed: 26822608
Nature. 2020 Jan;577(7789):249-253
pubmed: 31853066
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Cells. 2020 May 11;9(5):
pubmed: 32403417
Neurosci Biobehav Rev. 2020 Oct;117:253-278
pubmed: 29981347
Biol Psychiatry. 2017 Mar 1;81(5):442-451
pubmed: 26392128
J Leukoc Biol. 2005 Dec;78(6):1233-41
pubmed: 16314440
Prog Neurobiol. 2017 Feb - Mar;149-150:1-20
pubmed: 28143732
Neuroimage. 2011 Apr 15;55(4):1519-27
pubmed: 21167288
J Neuropathol Exp Neurol. 2001 Jan;60(1):25-32
pubmed: 11202173
Nat Cell Biol. 2001 Feb;3(2):150-7
pubmed: 11175747
Nature. 2006 Apr 20;440(7087):1054-9
pubmed: 16547515
Brain Behav Immun. 2015 Feb;44:1-8
pubmed: 25172555
Stem Cells. 2004;22(1):109-18
pubmed: 14688397
J Epidemiol Community Health. 2003 Sep;57(9):699-703
pubmed: 12933776
Lancet Psychiatry. 2017 Apr;4(4):339-346
pubmed: 27979720
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6728-6733
pubmed: 28607066
Lancet Neurol. 2014 Mar;13(3):330-8
pubmed: 24556010
Am J Psychiatry. 2008 Jan;165(1):59-65
pubmed: 18056223
Genes Immun. 2010 Jan;11(1):11-20
pubmed: 19847194
Biomark Med. 2013 Apr;7(2):247-60
pubmed: 23547820
Curr Opin Immunol. 2007 Jun;19(3):320-6
pubmed: 17433869
J Pers Assess. 1984 Feb;48(1):95-7
pubmed: 6707862
PLoS One. 2014 Apr 01;9(4):e92325
pubmed: 24691121
J Neurosci. 2007 Oct 3;27(40):10695-702
pubmed: 17913903
J Gynecol Obstet Biol Reprod (Paris). 2012 Jun;41(4):e1-e15
pubmed: 22613118
Curr Biol. 2017 Dec 18;27(24):3859-3863.e3
pubmed: 29199072
Early Hum Dev. 2000 Apr;58(1):25-39
pubmed: 10785334
BMC Immunol. 2008 Oct 17;9:59
pubmed: 18928527
Nature. 2016 Jul 21;535(7612):425-9
pubmed: 27409813
Biochim Biophys Acta. 2012 Jun;1822(6):831-42
pubmed: 22326556
Front Immunol. 2018 Jul 30;9:1759
pubmed: 30105028
Brain Res. 1993 Jan 8;600(1):49-55
pubmed: 8422590
Mol Psychiatry. 2017 Feb;22(2):273-279
pubmed: 27217154
Transl Psychiatry. 2019 Oct 7;9(1):252
pubmed: 31591381
Mol Autism. 2011 Aug 02;2:13
pubmed: 21810230
Brain Behav Immun. 2009 Oct;23(7):887-97
pubmed: 19389469
Cytokine. 2013 Feb;61(2):370-6
pubmed: 23267761
J Am Acad Child Adolesc Psychiatry. 2001 Nov;40(11):1337-45
pubmed: 11699809
BMC Bioinformatics. 2011 Mar 17;12:77
pubmed: 21414208
Nat Rev Neurol. 2014 Nov;10(11):643-60
pubmed: 25311587
Cereb Cortex. 2004 Jan;14(1):97-105
pubmed: 14654461
Transl Psychiatry. 2013 Jul 09;3:e280
pubmed: 23838891
Int J Environ Res Public Health. 2018 Jun 10;15(6):
pubmed: 29890784
Nat Rev Neurosci. 2015 Aug;16(8):469-86
pubmed: 26189694
Stem Cells. 2008 Sep;26(9):2361-71
pubmed: 18583543
J Youth Adolesc. 1991 Apr;20(2):149-66
pubmed: 24265004
Brain Behav Immun. 2020 Jul;87:377-387
pubmed: 31923553
Acta Psychiatr Scand. 2017 Feb;135(2):97-105
pubmed: 27870529
Front Neuroanat. 2019 Nov 19;13:95
pubmed: 31803028
Int J Occup Med Environ Health. 2015;28(3):419-43
pubmed: 26190723
Ann N Y Acad Sci. 2002 Jun;966:441-5
pubmed: 12114302
Biol Neonate. 1999 Nov;76(5):320-4
pubmed: 10516399
Glia. 2014 May;62(5):725-35
pubmed: 24677511
Eur J Epidemiol. 2010 Aug;25(8):569-80
pubmed: 20535529
J Neuroinflammation. 2014 Jun 20;11:113
pubmed: 24951035
Pediatrics. 2018 Sep;142(3):
pubmed: 30093539
J Pediatr. 2015 Jun;166(6):1440-8.e1
pubmed: 25866387
Paediatr Perinat Epidemiol. 2018 Jul;32(4):337-345
pubmed: 29972605
Neurochem Int. 2010 Nov;57(4):440-5
pubmed: 20193723
Neuron. 2009 Oct 15;64(1):61-78
pubmed: 19840550
Front Neurosci. 2016 Jul 28;10:344
pubmed: 27516732
Neurosci Lett. 2011 Jun 22;497(2):122-7
pubmed: 21543053
Neuropathol Appl Neurobiol. 2001 Apr;27(2):127-38
pubmed: 11437993
Neurosci Lett. 2006 Feb 6;394(1):22-7
pubmed: 16278045
Environ Health Perspect. 2017 Sep 15;125(9):097014
pubmed: 28937960
Brain Behav Immun. 2010 Nov;24(8):1340-6
pubmed: 20600810
Biol Psychiatry. 2019 Aug 15;86(4):255-264
pubmed: 31279535
Stem Cells. 2008 Sep;26(9):2444-54
pubmed: 18635871
Soc Psychiatry Psychiatr Epidemiol. 2009 Mar;44(3):231-8
pubmed: 18714424
Biol Psychiatry. 2019 Jan 15;85(2):107-121
pubmed: 30318336
Int J Epidemiol. 2016 Apr;45(2):353-63
pubmed: 26283636