Impact of a Lymph Node Specimen Collection Kit on the Distribution and Survival Implications of the Proposed Revised Lung Cancer Residual Disease Classification: A Propensity-Matched Analysis.
Lymphadenectomy
Pathologic nodal staging
Quality of care
Surgical resection
Survival
Journal
JTO clinical and research reports
ISSN: 2666-3643
Titre abrégé: JTO Clin Res Rep
Pays: United States
ID NLM: 101769967
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
21
02
2021
accepted:
21
02
2021
entrez:
30
9
2021
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
epublish
Résumé
The International Association for the Study of Lung Cancer (IASLC) has proposed a revision of the residual disease (R-factor) classification, to R0, 'R-uncertain', R1 and R2. We previously demonstrated longer survival after surgical resection with a lymph node specimen collection kit, and now evaluate R-factor redistribution as the mechanism of its survival benefit. We retrospectively evaluated surgical resections for lung cancer in the population-based observational 'Mid-South Quality of Surgical Resection' cohort from 2009-2019, including a full-cohort and propensity-score matched analysis. Of 3,505 resections, 34% were R0, 60% R-uncertain, and 6% R1 or R2. The R0 percentage increased from 9% in 2009 to 56% in 2019 ( A lymph node kit increased overall survival by increasing R0, reducing the probability of R-uncertain resections, and diminishing extreme R-uncertainty.
Identifiants
pubmed: 34590011
doi: 10.1016/j.jtocrr.2021.100161
pii: S2666-3643(21)00020-5
pmc: PMC8474412
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100161Subventions
Organisme : NCI NIH HHS
ID : R01 CA172253
Pays : United States
Informations de copyright
© 2021 The Authors.
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