Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease.
Alzheimer's disease
PET scans
RBANS
apolipoprotein B
cerebrospinal fluid
synaptic markers
tau pathology
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
30
06
2021
received:
16
12
2020
accepted:
05
07
2021
pubmed:
1
10
2021
medline:
11
5
2022
entrez:
30
9
2021
Statut:
ppublish
Résumé
We examine the role of brain apolipoprotein B (apoB) as a putative marker of early tau pathology and cognitive decline. Cerebrospinal fluid (CSF) samples from cognitively normal and Alzheimer's disease (AD) participants were collected to measure protein levels of apoB and AD biomarkers amyloid beta (Aβ), t-tau and p-tau, as well as synaptic markers GAP43, SYNAPTOTAGMIN-1, synaptosome associated protein 25 (SNAP-25), and NEUROGRANIN. CSF apoB levels were contrasted with positron emission tomography (PET) scan measures of Aβ (18F-NAV4694) and Tau (flortaucipir) along with cognitive assessment alterations over 6 to 8 years. CSF apoB levels were elevated in AD participants and correlated with t-tau, p-tau, and the four synaptic markers in pre-symptomatic individuals. In the latter, CSF apoB levels correlated with PET flortaucipir-binding in entorhinal, parahippocampal, and fusiform regions. Baseline CSF apoB levels were associated with longitudinal visuospatial cognitive decline. CSF apoB markedly associates with early tau dysregulation in asymptomatic subjects and identifies at-risk individuals predisposed to develop visuospatial cognitive decline over time.
Identifiants
pubmed: 34590423
doi: 10.1002/alz.12442
pmc: PMC9293308
doi:
Substances chimiques
APOB protein, human
0
Amyloid beta-Peptides
0
Apolipoprotein B-100
0
Apolipoproteins
0
Apolipoproteins B
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
875-887Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
ID : PJT 153287
Pays : Canada
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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