Autonomic modulation of ventricular electrical activity: recent developments and clinical implications.
Arrhythmogenesis
Cardiac electrophysiology
Neural remodeling
Sympathetic nerves
Journal
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
ISSN: 1619-1560
Titre abrégé: Clin Auton Res
Pays: Germany
ID NLM: 9106549
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
02
06
2021
accepted:
12
08
2021
pubmed:
1
10
2021
medline:
15
12
2021
entrez:
30
9
2021
Statut:
ppublish
Résumé
This review aimed to provide a complete overview of the current stance and recent developments in antiarrhythmic neuromodulatory interventions, focusing on lifethreatening vetricular arrhythmias. Both preclinical studies and clinical studies were assessed to highlight the gaps in knowledge that remain to be answered and the necessary steps required to properly translate these strategies to the clinical setting. Cardiac autonomic imbalance, characterized by chronic sympathoexcitation and parasympathetic withdrawal, destabilizes cardiac electrophysiology and promotes ventricular arrhythmogenesis. Therefore, neuromodulatory interventions that target the sympatho-vagal imbalance have emerged as promising antiarrhythmic strategies. These strategies are aimed at different parts of the cardiac neuraxis and directly or indirectly restore cardiac autonomic tone. These interventions include pharmacological blockade of sympathetic neurotransmitters and neuropeptides, cardiac sympathetic denervation, thoracic epidural anesthesia, and spinal cord and vagal nerve stimulation. Neuromodulatory strategies have repeatedly been demonstrated to be highly effective and very promising anti-arrhythmic therapies. Nevertheless, there is still much room to gain in our understanding of neurocardiac physiology, refining the current neuromodulatory strategic options and elucidating the chronic effects of many of these strategic options.
Identifiants
pubmed: 34591191
doi: 10.1007/s10286-021-00823-4
pii: 10.1007/s10286-021-00823-4
pmc: PMC8629778
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-676Subventions
Organisme : NIH HHS
ID : OT2 OD023848
Pays : United States
Organisme : NIH HHS
ID : OT2 OD028201
Pays : United States
Organisme : NIDA NIH HHS
ID : DP2 DA042423
Pays : United States
Informations de copyright
© 2021. The Author(s).
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