Clinical use of thrombin generation assays.
TGA
coagulation assay
hemostasis
thrombin generation assay
thrombosis
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
24
09
2021
received:
02
04
2021
accepted:
28
09
2021
pubmed:
1
10
2021
medline:
24
11
2021
entrez:
30
9
2021
Statut:
ppublish
Résumé
Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and even more specialized tests may not allow a relevant characterization of the hemostatic balance. In contrast, thrombin generation assay (TGA) is a global assay allowing the dynamic continuous and simultaneous recording of the combined effects of both thrombin generation and thrombin inactivation. TGA thus reflects the result of procoagulant and anticoagulant activities in blood and plasma. Because of this unique feature, TGA has been widely used in a wide array of settings from both research, clinical and pharmaceutical perspectives. This includes diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders. In addition, TGA has been shown to provide relevant information for the diagnosis of coagulopathies induced by infectious diseases, comprising also disturbance of the coagulation system in COVID-19, or for the assessment of early recurrence in breast cancer. This review article aims to document most clinical applications of TGA.
Identifiants
pubmed: 34592058
doi: 10.1111/jth.15538
pmc: PMC9292855
pii: S1538-7836(22)00556-6
doi:
Substances chimiques
Thrombin
EC 3.4.21.5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2918-2929Informations de copyright
© 2021 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.
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