Methods to Analyse Time-to-Event Data: The Kaplan-Meier Survival Curve.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
07
2021
accepted:
01
09
2021
entrez:
1
10
2021
pubmed:
2
10
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Studies performed in the field of oxidative medicine and cellular longevity frequently focus on the association between biomarkers of cellular and molecular mechanisms of oxidative stress as well as of aging, immune function, and vascular biology with specific time to event data, such as mortality and organ failure. Indeed, time-to-event analysis is one of the most important methodologies used in clinical and epidemiological research to address etiological and prognostic hypotheses. Survival data require adequate methods of analyses. Among these, the Kaplan-Meier analysis is the most used one in both observational and interventional studies. In this paper, we describe the mathematical background of this technique and the concept of censoring (right censoring, interval censoring, and left censoring) and report some examples demonstrating how to construct a Kaplan-Meier survival curve and how to apply this method to provide an answer to specific research questions.
Identifiants
pubmed: 34594473
doi: 10.1155/2021/2290120
pmc: PMC8478547
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2290120Informations de copyright
Copyright © 2021 Graziella D'Arrigo et al.
Déclaration de conflit d'intérêts
No conflict of interest is related to this manuscript.
Références
Biomed Res Int. 2014;2014:623487
pubmed: 24579083
Am J Nephrol. 2019;50(2):115-125
pubmed: 31238306
Nephron Clin Pract. 2009;113(3):c214-7
pubmed: 19690438
Am J Hematol. 2017 Mar;92(3):244-250
pubmed: 28006855
Cancers (Basel). 2019 Mar 28;11(4):
pubmed: 30925767
Biometrika. 1965 Jun;52:203-23
pubmed: 14341275
Nephrol Dial Transplant. 2010 May;25(5):1388-93
pubmed: 20067907
Pharmacol Res. 2016 Mar;105:210-5
pubmed: 26827824
Oxid Med Cell Longev. 2020 Aug 5;2020:2701539
pubmed: 32831992
Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii1-ii5
pubmed: 28339854
BMJ. 2004 May 1;328(7447):1073
pubmed: 15117797
Antioxidants (Basel). 2018 Aug 24;7(9):
pubmed: 30149498