Use of electrochemotherapy in a combined surgical treatment of local recurrence of rectal cancer.
Journal
Journal of surgical case reports
ISSN: 2042-8812
Titre abrégé: J Surg Case Rep
Pays: England
ID NLM: 101560169
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
08
07
2021
revised:
12
08
2021
accepted:
19
08
2021
entrez:
1
10
2021
pubmed:
2
10
2021
medline:
2
10
2021
Statut:
epublish
Résumé
Recurrence of rectal cancer (RRC) affects up to one-third of patients. The survival is strictly dependent on the possibility of performing surgery without microscopic tumor residues (R0). Electrochemotherapy (ECT) is based on the effect that electric pulsations have on increasing the permeability of the cell membrane to certain drugs. We propose the association of ECT to the surgical excision of perineal RRC in a 72-year-old male patient. Given the proximity between the recurrence and the urethra, it was decided to use ECT in order to clean any further neoplastic residues 10 mm from the surgical resection margin. Pelvic MRI at 4 and 7 months and clinical follow-up conducted for 9 months did not document disease recurrence. ECT combined with surgery can prove to be a valid choice in selected cases and could be the best treatment the patient is willing to accept.
Identifiants
pubmed: 34594489
doi: 10.1093/jscr/rjab403
pii: rjab403
pmc: PMC8478475
doi:
Types de publication
Case Reports
Langues
eng
Pagination
rjab403Informations de copyright
Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2021.
Références
BMC Surg. 2013 Sep 30;13:43
pubmed: 24073705
Colorectal Dis. 2006 Nov;8(9):733-47
pubmed: 17032318
Biochem Pharmacol. 1988 Dec 15;37(24):4727-33
pubmed: 2462423
J Contemp Brachytherapy. 2017 Dec;9(6):497-498
pubmed: 29441092
Br J Cancer. 2018 Oct;119(9):1044-1051
pubmed: 30356125
Annu Rev Biomed Eng. 2014 Jul 11;16:295-320
pubmed: 24905876