Haploidentical Hematopoietic Stem Cell Transplantation Followed by 'Post-Cyclophosphamide': The Future of Allogeneic Stem Cell Transplant.
Allogeneic
Haploidentical
Posttransplant cyclophosphamide
Journal
Clinical hematology international
ISSN: 2590-0048
Titre abrégé: Clin Hematol Int
Pays: England
ID NLM: 101759455
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
05
02
2020
accepted:
28
03
2020
entrez:
1
10
2021
pubmed:
19
4
2020
medline:
19
4
2020
Statut:
epublish
Résumé
Allogeneic hematopoietic cell transplant (Allo-HCT) is a potentially curative therapy for many malignant and nonmalignant hematological diseases. However, a suitable human leukocyte antigens (HLAs)-matched donor may not be available when the patient is in urgent need of a stem cell transplant. This challenge has been ameliorated to a large extent by the introduction of haploidentical donors. This type of donor shares one HLA haplotype with the recipient. Therefore, a patient's full sibling has a 50% chance of being haploidentical and a patient's biologic parents and children will all be haploidentical, thus providing an immediately accessible, motivated donor for almost every recipient. Haploidentical transplants previously incurred prohibitively poor outcomes, preventing their widespread use. However, several recent advances have dramatically improved the results, making them a more viable donor source. In this review, we discuss different types of donors used for Allo-HCT with a particular focus on the use of haploidentical donors and their future potential.
Identifiants
pubmed: 34595443
doi: 10.2991/chi.d.200405.001
pii: CHI-2-2-49
pmc: PMC8432344
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
49-58Informations de copyright
© 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Déclaration de conflit d'intérêts
No conflicts of interest relevant for this paper from both authors.
Références
Am J Hematol. 2018 Oct;93(10):1236-1244
pubmed: 30058714
Infection. 2017 Aug;45(4):403-411
pubmed: 28417421
Biol Blood Marrow Transplant. 2019 Jul;25(7):1456-1464
pubmed: 30878605
J Clin Oncol. 2016 Sep 10;34(26):3141-9
pubmed: 27269951
Bone Marrow Transplant. 2016 Aug;51(8):1134-6
pubmed: 26999460
Cancer. 2020 Mar 1;126(5):1004-1015
pubmed: 31774557
J Hematol Oncol. 2018 Aug 30;11(1):110
pubmed: 30165887
Bone Marrow Transplant. 2014 Feb;49(2):168-73
pubmed: 23892326
Oncotarget. 2017 Jun 29;8(38):63574-63586
pubmed: 28969012
Blood. 2007 Dec 15;110(13):4576-83
pubmed: 17785583
Biol Blood Marrow Transplant. 2001;7(1):45-8
pubmed: 11215698
Blood. 2013 Feb 7;121(6):1059-64
pubmed: 23247725
Transplantation. 2009 Oct 27;88(8):1019-24
pubmed: 19855248
Leukemia. 2003 Aug;17(8):1596-9
pubmed: 12886248
Transplantation. 2004 Mar 27;77(6):874-80
pubmed: 15077030
Biol Blood Marrow Transplant. 2002;8(5):257-60
pubmed: 12064362
Bone Marrow Transplant. 2013 Feb;48(2):210-9
pubmed: 22484322
N Engl J Med. 1998 Nov 26;339(22):1565-77
pubmed: 9828244
Biol Blood Marrow Transplant. 2016 Nov;22(11):2047-2055
pubmed: 27522040
Ann Hematol. 2015 Oct;94(10):1699-705
pubmed: 26152553
Bone Marrow Transplant. 1991 Jun;7(6):443-52
pubmed: 1873591
Transpl Infect Dis. 2005 Mar;7(1):11-7
pubmed: 15984943
Cancer. 2015 Jun 1;121(11):1809-16
pubmed: 25649994
Biol Blood Marrow Transplant. 2015 Aug;21(8):1506-14
pubmed: 26001696
Bone Marrow Transplant. 2017 May;52(5):689-696
pubmed: 28067872
J Clin Oncol. 2017 Oct 20;35(30):3425-3432
pubmed: 28846465
Biol Blood Marrow Transplant. 2012 Aug;18(8):1150-63
pubmed: 22510384
Curr Stem Cell Res Ther. 2008 Dec;3(4):237-46
pubmed: 19075754
Leuk Res. 2017 Aug;59:41-46
pubmed: 28549237
Jpn J Clin Oncol. 2019 Oct 1;49(10):924-931
pubmed: 31265729
J Allergy Clin Immunol. 2018 Jul;142(1):159-170.e2
pubmed: 29518427
Biol Blood Marrow Transplant. 2019 Jan;25(1):114-120
pubmed: 30172776
Blood Adv. 2017 Feb 28;1(7):477-485
pubmed: 29296964
Blood. 2002 Mar 1;99(5):1572-7
pubmed: 11861270
Sci Transl Med. 2013 Nov 13;5(211):211ra157
pubmed: 24225944
Clin Cancer Res. 2018 Jun 15;24(12):2794-2803
pubmed: 29555662
Haematologica. 2016 Oct;101(10):1260-1266
pubmed: 27354023
Biol Blood Marrow Transplant. 2007 Aug;13(8):965-74
pubmed: 17640601
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S37-9
pubmed: 26039205
Blood. 2015 May 14;125(20):3173-82
pubmed: 25769621
N Engl J Med. 1985 Sep 26;313(13):765-71
pubmed: 3897863
Biol Blood Marrow Transplant. 2016 Oct;22(10):1851-1860
pubmed: 27318038
Sci China Life Sci. 2019 May;62(5):691-697
pubmed: 30194676
Transplantation. 1991 Mar;51(3):716-24
pubmed: 2006531
J Hematol Oncol. 2018 Apr 16;11(1):55
pubmed: 29661208
Biol Blood Marrow Transplant. 2018 Mar;24(3):549-554
pubmed: 29247781
Haematologica. 2018 Aug;103(8):1317-1328
pubmed: 29748438
Biol Blood Marrow Transplant. 2018 Jul;24(7):1449-1454
pubmed: 29448057
Mediterr J Hematol Infect Dis. 2016 Oct 25;8(1):e2016057
pubmed: 27872737
Lancet Oncol. 2012 Apr;13(4):366-74
pubmed: 22340965
Oncoimmunology. 2015 Mar 20;4(3):e974393
pubmed: 25949893
Cancer. 2016 Nov 15;122(21):3316-3326
pubmed: 27404668
Br J Haematol. 2009 Oct;147(2):246-61
pubmed: 19796274
Leukemia. 2015 Sep;29(9):1891-900
pubmed: 25882700
J Allergy Clin Immunol. 2004 Aug;114(2):371-6
pubmed: 15316518
J Hematol Oncol. 2015 Jul 10;8:84
pubmed: 26156584
Blood. 2008 Nov 1;112(9):3574-81
pubmed: 18606875
Mil Med. 2016 Nov;181(11):e1685-e1691
pubmed: 27849508
Bone Marrow Transplant. 2018 Apr;53(4):422-430
pubmed: 29330396
N Engl J Med. 2014 Jul 24;371(4):339-48
pubmed: 25054717
Bone Marrow Transplant. 2012 Nov;47(11):1459-64
pubmed: 22410750
Am J Transplant. 2007 Apr;7(4):864-71
pubmed: 17391129
Lancet. 1983 Mar 19;1(8325):612-5
pubmed: 6131300
Haematologica. 2017 Feb;102(2):401-410
pubmed: 27758821
Leukemia. 2019 Jan;33(1):230-239
pubmed: 29907809
J Hematol Oncol. 2017 Jan 19;10(1):24
pubmed: 28103944
Blood. 1990 May 15;75(10):1947-50
pubmed: 2337669
Bone Marrow Transplant. 2019 Mar;54(3):432-441
pubmed: 30087460
Blood. 2004 Feb 15;103(4):1417-24
pubmed: 14576061
Biol Blood Marrow Transplant. 2018 Aug;24(8):1664-1670
pubmed: 29680516
Transplantation. 1995 Oct 27;60(8):778-83
pubmed: 7482734
Lancet. 2007 Jun 9;369(9577):1947-54
pubmed: 17560447
Transfus Med. 2008 Aug;18(4):250-9
pubmed: 18783584