Master regulators of skeletal muscle lineage development and pluripotent stem cells differentiation.
ESC
MRF
MYF5
MYOD
MYOG
Muscle progenitor
Myogenesis
PAX3
PAX7
hiPSC
Journal
Cell regeneration (London, England)
ISSN: 2045-9769
Titre abrégé: Cell Regen
Pays: China
ID NLM: 101627311
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
received:
03
06
2021
accepted:
24
08
2021
entrez:
1
10
2021
pubmed:
2
10
2021
medline:
2
10
2021
Statut:
epublish
Résumé
In vertebrates, the skeletal muscles of the body and their associated stem cells originate from muscle progenitor cells, during development. The specification of the muscles of the trunk, head and limbs, relies on the activity of distinct genetic hierarchies. The major regulators of trunk and limb muscle specification are the paired-homeobox transcription factors PAX3 and PAX7. Distinct gene regulatory networks drive the formation of the different muscles of the head. Despite the redeployment of diverse upstream regulators of muscle progenitor differentiation, the commitment towards the myogenic fate requires the expression of the early myogenic regulatory factors MYF5, MRF4, MYOD and the late differentiation marker MYOG. The expression of these genes is activated by muscle progenitors throughout development, in several waves of myogenic differentiation, constituting the embryonic, fetal and postnatal phases of muscle growth. In order to achieve myogenic cell commitment while maintaining an undifferentiated pool of muscle progenitors, several signaling pathways regulate the switch between proliferation and differentiation of myoblasts. The identification of the gene regulatory networks operating during myogenesis is crucial for the development of in vitro protocols to differentiate pluripotent stem cells into myoblasts required for regenerative medicine.
Identifiants
pubmed: 34595600
doi: 10.1186/s13619-021-00093-5
pii: 10.1186/s13619-021-00093-5
pmc: PMC8484369
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
31Informations de copyright
© 2021. The Author(s).
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