The Association of Childhood Maltreatment, Sex, and Hair Cortisol Concentrations With Trajectories of Depressive and Anxious Symptoms Among Adult Psychiatric Inpatients.
Journal
Psychosomatic medicine
ISSN: 1534-7796
Titre abrégé: Psychosom Med
Pays: United States
ID NLM: 0376505
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
pubmed:
2
10
2021
medline:
1
4
2022
entrez:
1
10
2021
Statut:
ppublish
Résumé
Depression and anxiety symptoms are commonly observed among clinical populations, especially among women and maltreated individuals. Few investigations have, however, assessed the existence of distinct symptoms trajectories among clinical populations and how these relate to childhood maltreatment, sex differences, and stress physiology indexed by hair cortisol concentrations (HCCs). The current study a) identified distinct depression and anxious trajectories in a sample of psychiatric inpatients followed up prospectively from their admission to a psychiatric emergency service, and b) examined whether HCC, childhood maltreatment, and sex independently and jointly predict these trajectories. Adult inpatients (n = 402; 55% women) were recruited upon admission to psychiatric emergency service (T1) during which HCC (reflecting cortisol secretion for the last 3 months), childhood maltreatment, and depression and anxiety symptoms were assessed. Symptoms were reevaluated when patients were discharged from the hospital (T2), admitted to outpatient clinics (T3), and 12 months later or at the end of outpatient treatment (T4). Three trajectories were identified for depression and anxiety symptoms. Among men, higher HCC predicted higher odds of evincing chronic depressive symptoms compared with a low stable trajectory (odds ratio [OR] = 3.46, 95% confidence interval [CI] = 1.43-8.40). Greater childhood maltreatment among men predicted higher chances of exhibiting chronic anxious symptoms than the low stable (OR = 1.47, 95% CI = 1.07-2.02) and the high decreasing trajectories (OR = 0.70, 95% CI = 0.51-0.95). Opposite findings were noted for women. Childhood maltreatment and HCC should be further investigated as predictors of anxious and depressive trajectories, during which sex-specific associations ought to be considered.
Identifiants
pubmed: 34596058
doi: 10.1097/PSY.0000000000001016
pii: 00006842-202201000-00004
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-28Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society.
Références
World Health Organization. WHO | Depression and Other Common Mental Disorders. 2017. Available at: https://www.who.int/mental_health/management/depression/prevalence_global_health_estimates/en/ . Accessed December 13, 2019.
Lupien SJ, Sasseville M, François N, Giguère CE, Boissonneault J, Plusquellec P, Godbout R, Xiong L, Potvin S, Kouassi E, Lesage A; The Signature Consortium. The DSM5/RDoC debate on the future of mental health research: implication for studies on human stress and presentation of the signature bank. Stress 2017;20:2–18.
Musliner KL, Munk-Olsen T, Eaton WW, Zandi PP. Heterogeneity in long-term trajectories of depressive symptoms: patterns, predictors and outcomes. J Affect Disord 2016;192:199–211.
Jalnapurkar I, Allen M, Pigott T. Sex differences in anxiety disorders: a review. J Psychiatry Depress Anxiety 2018;4:12.
Kuehner C. Why is depression more common among women than among men?Lancet Psychiatry 2017;4:146–58.
Li M, D’Arcy C, Meng X. Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol Med 2016;46:717–30.
Nanni V, Uher R, Danese A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 2012;169:141–51.
McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med 1993;153:2093–101.
Raymond C, Marin M-F, Majeur D, Lupien S. Early child adversity and psychopathology in adulthood: HPA axis and cognitive dysregulations as potential mechanisms. Prog Neuropsychopharmacol Biol Psychiatry 2018;85:152–60.
Zorn JV, Schür RR, Boks MP, Kahn RS, Joëls M, Vinkers CH. Cortisol stress reactivity across psychiatric disorders: a systematic review and meta-analysis. Psychoneuroendocrinology 2017;77:25–36.
Dedovic K, Ngiam J. The cortisol awakening response and major depression: examining the evidence. Neuropsychiatr Dis Treat 2015;11:1181–9.
Adam EK, Quinn ME, Tavernier R, McQuillan MT, Dahlke KA, Gilbert KE. Diurnal cortisol slopes and mental and physical health outcomes: a systematic review and meta-analysis. Psychoneuroendocrinology 2017;83:25–41.
Elnazer HY, Baldwin DS. Investigation of cortisol levels in patients with anxiety disorders: a structured review. In: Pariante CM, Lapiz-Bluhm MD, editors. Behavioral Neurobiology of Stress-Related Disorders [Internet]. Berlin, Heidelberg: Springer; 2014:191–216. Current topics in behavioral neurosciences. Available at: https://doi.org/10.1007/7854_2014_299 . Accessed November 17, 2020.
Stetler C, Miller GE. Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med 2011;73:114–26.
Carnegie R, Araya R, Ben-Shlomo Y, Glover V, O’Connor TG, O’Donnell KJ, Pearson R, Lewis G. Cortisol awakening response and subsequent depression: prospective longitudinal study. Br J Psychiatry 2014;204:137–43.
Ciufolini S, Dazzan P, Kempton MJ, Pariante C, Mondelli V. HPA axis response to social stress is attenuated in schizophrenia but normal in depression: evidence from a meta-analysis of existing studies. Neurosci Biobehav Rev 2014;47:359–68.
Gerritsen L, Staufenbiel SM, Penninx BWJH, van Hemert AM, Noppe G, de Rijke YB, van Rossum EFC. Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders. Psychoneuroendocrinology 2019;101:246–52.
Koss KJ, Gunnar MR. Annual research review: early adversity, the hypothalamic-pituitary-adrenocortical axis, and child psychopathology. J Child Psychol Psychiatry 2018;59:327–46.
Stalder T, Steudte-Schmiedgen S, Alexander N, Klucken T, Vater A, Wichmann S, Kirschbaum C, Miller R. Stress-related and basic determinants of hair cortisol in humans: a meta-analysis. Psychoneuroendocrinology 2017;77:261–74.
Malisiova EK, Mourikis I, Darviri C, Nicolaides NC, Zervas IM, Papageorgiou C, Chrousos GP. Hair cortisol concentrations in mental disorders: a systematic review. Physiol Behav 2020;229:113244.
Staufenbiel SM, Penninx BWJH, Spijker AT, Elzinga BM, van Rossum EFC. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology 2013;38:1220–35.
Ursache A, Merz EC, Melvin S, Meyer J, Noble KG. Socioeconomic status, hair cortisol and internalizing symptoms in parents and children. Psychoneuroendocrinology 2017;78:142–50.
Rhebergen D, Lamers F, Spijker J, de Graaf R, Beekman ATF, Penninx BWJH. Course trajectories of unipolar depressive disorders identified by latent class growth analysis. Psychol Med 2012;42:1383–96.
Santacana M, Arias B, Mitjans M, Bonillo A, Montoro M, Rosado S, Guillamat R, Vallès V, Pérez V, Forero CG, Fullana MA. Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment. PLoS One 2016;11:e0158224.
Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, Sondeijker FEPL, Ormel J, Verhulst FC. Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 2007;116:137–44.
Iob E, Kirschbaum C, Steptoe A. Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms. Mol Psychiatry 2020;25:1130–40.
Walsh CA, MacMillan HL, Trocmé N, Jamieson E, Boyle MH. Measurement of victimization in adolescence: development and validation of the childhood experiences of violence questionnaire. Child Abuse Negl 2008;32:1037–57.
Spitzer RL, Kroenke K, Williams JBW; Group and the PHQPCS. Validation and utility of a self-report version of PRIME-MD: the PHQ Primary Care Study. JAMA 1999;282:1737–44.
Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Scale. Palo Alto, CA: Consulting Psychologists; 1983.
Kirschbaum C, Tietze A, Skoluda N, Dettenborn L. Hair as a retrospective calendar of cortisol production—increased cortisol incorporation into hair in the third trimester of pregnancy. Psychoneuroendocrinology 2009;34:32–7.
Ouellet-Morin I, Cantave C, Paquin S, Geoffroy M-C, Brendgen M, Vitaro F, Tremblay R, Boivin M, Lupien S, Côté S. Associations between developmental trajectories of peer victimization, hair cortisol, and depressive symptoms: a longitudinal study. J Child Psychol Psychiatry [Internet] 2021;62:19–27. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpp.13228 . Accessed April 14, 2020.
doi: 10.1111/jcpp.13228
Nagin DS, Odgers CL. Group-based trajectory modeling in clinical research. Annu Rev Clin Psychol [Internet] 2010;6:109–38. Available at: https://www.annualreviews.org/doi/abs/10.1146/annurev.clinpsy.121208.131413 . Accessed July 16, 2019.
doi: 10.1146/annurev.clinpsy.121208.131413
Mustonen P, Karlsson L, Kataja E-L, Scheinin NM, Kortesluoma S, Coimbra B, Rodrigues AJ, Sousa N, Karlsson H. Maternal prenatal hair cortisol is associated with prenatal depressive symptom trajectories. Psychoneuroendocrinology 2019;109:104383.
Gerritsen L, Milaneschi Y, Vinkers CH, van Hemert AM, van Velzen L, Schmaal L, Wjh Penninx BW. HPA axis genes, and their interaction with childhood maltreatment, are related to cortisol levels and stress-related phenotypes. Neuropsychopharmacology 2017;42:2446–55.
Juster R-P, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin M-F, Wan N, Sekerovic Z, Lord C, Fiocco AJ, Plusquellec P, McEwen BS, Lupien SJ. A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Dev Psychopathol 2011;23:725–76.
Teicher MH, Samson JA, Anderson CM, Ohashi K. The effects of childhood maltreatment on brain structure, function and connectivity. Nat Rev Neurosci 2016;17:652–66.
Dismukes AR, Johnson MM, Vitacco MJ, Iturri F, Shirtcliff EA. Coupling of the HPA and HPG axes in the context of early life adversity in incarcerated male adolescents. Dev Psychobiol 2015;57:705–18.
Pochigaeva K, Druzhkova T, Yakovlev A, Onufriev M, Grishkina M, Chepelev A, Guekht A, Gulyaeva N. Hair cortisol as a marker of hypothalamic-pituitary-adrenal axis activity in female patients with major depressive disorder. Metab Brain Dis 2017;32:577–83.
Fischer S, King S, Papadopoulos A, Hotopf M, Young AH, Cleare AJ. Hair cortisol and childhood trauma predict psychological therapy response in depression and anxiety disorders. Acta Psychiatr Scand 2018;138:526–35.
Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology 2005;30:1010–6.
Shenk CE, Noll JG, Putnam FW, Trickett PK. A prospective examination of the role of childhood sexual abuse and physiological asymmetry in the development of psychopathology. Child Abuse Negl 2010;34:752–61.
Teicher MH, Samson JA. Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and Neurobiologically distinct subtypes. Am J Psychiatry 2013;170:1114–33.
Holz NE, Boecker-Schlier R, Buchmann AF, Blomeyer D, Jennen-Steinmetz C, Baumeister S, Plichta MM, Cattrell A, Schumann G, Esser G, Schmidt M, Buitelaar J, Meyer-Lindenberg A, Banaschewski T, Brandeis D, Laucht M. Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder. Soc Cogn Affect Neurosci 2017;12:261–72.
Jones AP, Laurens KR, Herba CM, Barker GJ, Viding E. Amygdala hypoactivity to fearful faces in boys with conduct problems and callous-unemotional traits. Am J Psychiatry 2009;166:95–102.
Wardenaar KJ, Vreeburg SA, van Veen T, Giltay EJ, Veen G, Penninx BWJH, Zitman FG. Dimensions of depression and anxiety and the hypothalamo-pituitary-adrenal axis. Biol Psychiatry 2011;69:366–73.
Tarullo AR, Gunnar MR. Child maltreatment and the developing HPA axis. Horm Behav 2006;50:632–9.
World Health Organization. WHO | Gender and Women’s Mental Health. Geneva, Switzerland: World Health Organization. Available at: https://www.who.int/mental_health/prevention/genderwomen/en/ . Accessed July 27, 2020.
Hemingway H, Croft P, Perel P, Hayden JA, Abrams K, Timmis A, Briggs A, Udumyan R, Moons KGM, Steyerberg EW, Roberts I, Schroter S, Altman DG, Riley RD. Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes. BMJ [Internet] 2013;346:e5595. Available at: https://www.bmj.com/content/346/bmj.e5595 . Accessed November 16, 2020.