Atlas of receptor genes expressed by the bovine morula and corresponding ligand-related genes expressed by uterine endometrium.
cell signaling
embryo
endometrium
morula
receptors
Journal
Molecular reproduction and development
ISSN: 1098-2795
Titre abrégé: Mol Reprod Dev
Pays: United States
ID NLM: 8903333
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
04
09
2021
received:
20
07
2021
accepted:
06
09
2021
pubmed:
2
10
2021
medline:
5
4
2022
entrez:
1
10
2021
Statut:
ppublish
Résumé
Regulation of the mammalian embryo involves cell-signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand-related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly-expressed pairs of endometrial ligand and embryo receptor genes included MDK and its receptors ITGB1, SDC4 and LRP2, WNT5A (RYK), VEGFA (ITGB1), GPI (AMFR), and the hedgehog proteins IHH and DHH (HHIP). The most highly expressed receptors for small molecules were GPRC5C (retinoic acid receptor), PGRMC1 (progesterone), and CHRNB2 (acetylcholine). There were also 84 genes encoding for cell signaling ligands expressed by the morula, with the most highly expressed being GPI, AIMP1, TIMP1, IK, and CCN2. The atlas of receptor and ligand genes should prove useful for understanding details of the communication between the embryo and mother that underlies optimal embryonic development.
Identifiants
pubmed: 34596291
doi: 10.1002/mrd.23534
pmc: PMC8558826
mid: NIHMS1741152
doi:
Substances chimiques
Hedgehog Proteins
0
Ligands
0
Membrane Proteins
0
PGRMC1 protein, human
0
Receptors, Progesterone
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
694-704Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R017522/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD088352
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD102533
Pays : United States
Informations de copyright
© 2021 The Authors. Molecular Reproduction and Development published by Wiley Periodicals LLC.
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