Gross motor function in children with Congenital Zika Syndrome from Rio de Janeiro, Brazil.
Neurodevelopmental disorders
Zika
Zika virus infection
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
18
03
2021
accepted:
22
09
2021
revised:
26
08
2021
pubmed:
2
10
2021
medline:
10
2
2022
entrez:
1
10
2021
Statut:
ppublish
Résumé
Congenital Zika Syndrome (CZS) is characterized by many impairments especially in the central nervous system, potentially compromising neurodevelopment and causing significant morbidity in affected children. The aim was to assess gross motor function in children with CZS. This was a cross-sectional investigation nested within a prospective cohort study of children with CZS based in a Brazilian referral hospital in Rio de Janeiro. Between March/2017 and February/2018, we performed gross motor function assessments using the Gross Motor Function Classification (GMFCS) and the Gross Motor Function Measure (GMFM), estimating the mean and standard deviation of GMFM scores among GMFCS groups. The study sample included 72 children, with a median age of 13 months (7-25). Of these, 63 (87.5%) had severe motor impairment, 3 (4%) had moderate impairment, and 6 (8%) had mild impairment. The mean GMFM score for each group was respectively 11.6, 26.1, and 81.6, with statistically significant differences (p-value < 0.001). Severely affected children only achieved head control in the sitting posture when supported. Children with milder forms were able to develop walking skills.Conclusion: Most children with CZS have major motor disabilities and a poor prognosis. Better understanding of limitations and functionality in children with CZS can serve as a prognostic guide in their management. What is Known: • Severe motor impairment was present in 63 (87.5%) children with CZS. • The degree of neurological impairment was inversely associated with motor performance. What is New: • Microcephaly was more frequent among children with severe gross motor function impairment. • Children with CZS have major motor disabilities and a poor prognosis.
Identifiants
pubmed: 34596742
doi: 10.1007/s00431-021-04270-1
pii: 10.1007/s00431-021-04270-1
pmc: PMC8821062
mid: NIHMS1745825
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-788Subventions
Organisme : the European Union's Horizon 2020 research and innovation program
ID : 734584
Organisme : CNPQ
ID : 441098/2016-9
Organisme : NIAID NIH HHS
ID : R01 AI140718
Pays : United States
Organisme : Wellcome Trust
ID : 205377/Z/16/Z
Pays : United Kingdom
Organisme : CNPQ
ID : 305090/2016-0
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Faperj
ID : E_18/2015TXB
Informations de copyright
© 2021. The Author(s).
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