Control Release and Diffusion-Reaction Kinetics of Genipin-Eluting Fibers Using an
aneurysm
controlled release
endovascular coiling
genipin
poly(ethylene-co-vinyl acetate)
Journal
ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670
Informations de publication
Date de publication:
08 11 2021
08 11 2021
Historique:
pubmed:
2
10
2021
medline:
12
11
2021
entrez:
1
10
2021
Statut:
ppublish
Résumé
The minimally invasive treatment of intracranial aneurysms by endovascular coiling is attractive yet faces challenges related to the degradation of fibrin clots in the aneurysm sac over time. Fibrin gels cross-linked with genipin exhibit enhanced mechanical and chemical stability, but there are many unknowns related to best practices for delivery from endovascular devices and subsequent integration of cross-linkers with the nascent clot. Here, we describe the
Identifiants
pubmed: 34597026
doi: 10.1021/acsbiomaterials.1c00773
doi:
Substances chimiques
Cross-Linking Reagents
0
Iridoids
0
genipin
A3V2NE52YG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5144-5153Subventions
Organisme : NINDS NIH HHS
ID : R44 NS107111
Pays : United States