Pituitary Adenylate Cyclase Activating Polypeptide Inhibits A

Animals Dopaminergic Neurons / metabolism Hypothalamus / metabolism Male Mice Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / metabolism Ventral Tegmental Area / metabolism
binge eating dopamine estradiol obesity pituitary adenylate cyclase-activating polypeptide sex difference

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 04 06 2021
revised: 20 09 2021
accepted: 21 09 2021
pubmed: 2 10 2021
medline: 20 1 2022
entrez: 1 10 2021
Statut: ppublish

Résumé

Pituitary adenylate cyclase-activating polypeptide (PACAP) binds to PACAP-specific (PAC1) receptors in multiple hypothalamic areas, especially those regulating energy balance. PACAP neurons in the ventromedial nucleus (VMN) exert anorexigenic effects within the homeostatic energy balance circuitry. Since PACAP can also reduce the consumption of palatable food, we tested the hypothesis that VMN PACAP neurons project to the ventral tegmental area (VTA) to inhibit A

Identifiants

DOI: 10.1016/j.neuroscience.2021.09.016 PMID: 34597709 PMC: PMC8608708
pubmed: 34597709
pii: S0306-4522(21)00483-8
doi: 10.1016/j.neuroscience.2021.09.016
pmc: PMC8608708
mid: NIHMS1745943
pii:
doi:

Substances chimiques

Pituitary Adenylate Cyclase-Activating Polypeptide 0
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide 0
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

49-64

Subventions

Organisme : NIDA NIH HHS
ID : R15 DA024314
Pays : United States

Informations de copyright

Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

Références

Endocrinology. 2018 Feb 1;159(2):647-664
pubmed: 29165691
J Neurosci. 2010 Jan 27;30(4):1560-5
pubmed: 20107083
Neuroendocrinology. 2013;97(2):160-75
pubmed: 22538462
Mov Disord. 2015 Jan;30(1):90-102
pubmed: 25491470
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1249-54
pubmed: 19164587
Behav Brain Res. 2006 Apr 25;169(1):111-9
pubmed: 16445991
Neuropharmacology. 2012 Jul;63(1):87-96
pubmed: 22138162
Neuroscience. 2005;134(3):737-44
pubmed: 15987666
Neuroendocrinology. 2021;111(1-2):45-69
pubmed: 32028278
Neurosci Lett. 1991 May 27;126(2):103-6
pubmed: 1922918
Front Biol (Beijing). 2015 Apr;10(2):165-176
pubmed: 29750082
J Neurosci. 2010 Feb 17;30(7):2472-9
pubmed: 20164331
Biochem Biophys Res Commun. 1999 Mar 24;256(3):664-7
pubmed: 10080956
Nat Rev Neurosci. 2017 Nov 16;18(12):741-752
pubmed: 29142296
Int J Mol Sci. 2021 Mar 08;22(5):
pubmed: 33800452
Neuropharmacology. 2010 Sep;59(3):190-200
pubmed: 20510254
Front Neurosci. 2013 May 23;7:85
pubmed: 23734095
Peptides. 2005 Sep;26(9):1611-6
pubmed: 16112400
Neuropsychopharmacology. 2011 Jan;36(2):459-71
pubmed: 20927047
Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1625-34
pubmed: 21957159
Eur J Neurosci. 2017 Dec;46(11):2746-2753
pubmed: 29057540
Physiol Rev. 2010 Jan;90(1):291-366
pubmed: 20086079
Physiol Behav. 2010 Jan 12;99(1):142-5
pubmed: 19840812
Mol Psychiatry. 2020 May;25(5):1006-1021
pubmed: 31485012
Mov Disord. 2019 Jun;34(6):821-831
pubmed: 31002748
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2520-5
pubmed: 26884159
Cell Metab. 2009 Aug;10(2):89-98
pubmed: 19656487
Physiol Behav. 1994 Sep;56(3):523-7
pubmed: 7972403
Int J Eat Disord. 2011 Apr;44(3):203-11
pubmed: 20186718
J Mol Neurosci. 2014 Nov;54(3):443-50
pubmed: 24744252
Neuron. 2006 Jan 19;49(2):191-203
pubmed: 16423694
Acta Pharmacol Sin. 2013 Jan;34(1):24-32
pubmed: 23123646
Neuropsychopharmacology. 2008 Nov;33(12):3010-20
pubmed: 18256592
PLoS One. 2011 May 05;6(5):e19600
pubmed: 21573180
Neuropeptides. 2008 Jun;42(3):267-76
pubmed: 18440632
Neurosci Lett. 2003 Sep 4;348(1):25-8
pubmed: 12893417
Neuroimage. 2004 Apr;21(4):1790-7
pubmed: 15050599
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E202-10
pubmed: 19435852
J Clin Invest. 2008 May;118(5):1796-805
pubmed: 18382766
Arch Gen Psychiatry. 2011 Aug;68(8):808-16
pubmed: 21464344
J Neurosci. 2009 Nov 25;29(47):14828-35
pubmed: 19940178
Pharmacol Rep. 2015 Jun;67(3):504-12
pubmed: 25933962
Neuroendocrinology. 2016;103(6):787-805
pubmed: 26765570
Brain Res. 2007 Dec;1186:203-11
pubmed: 18001699
Eur J Neurosci. 1999 Dec;11(12):4389-97
pubmed: 10594666
Pharmacol Rev. 2009 Sep;61(3):283-357
pubmed: 19805477
Physiol Behav. 2021 Jan 1;228:113183
pubmed: 32979341
Peptides. 1992 Nov-Dec;13(6):1133-5
pubmed: 1494495
Physiol Behav. 2017 Aug 1;177:305-316
pubmed: 28366814
J Neurosci. 2017 Dec 6;37(49):11854-11866
pubmed: 29089444
Nat Neurosci. 2004 May;7(5):493-4
pubmed: 15097991
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6772-7
pubmed: 19342492
Endocrinology. 2002 Feb;143(2):607-14
pubmed: 11796516
Cell Metab. 2014 Apr 1;19(4):682-93
pubmed: 24703699
Biol Sex Differ. 2019 Feb 12;10(1):9
pubmed: 30755252
Trends Endocrinol Metab. 2016 Sep;27(9):620-632
pubmed: 27166671
Neuropsychopharmacology. 2009 Jan;34(2):424-35
pubmed: 18536705
J Neurosci. 2007 Oct 10;27(41):11075-82
pubmed: 17928449
J Clin Invest. 2006 Jul;116(7):1886-901
pubmed: 16794735
Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15;309(10):G816-25
pubmed: 26336928
JAMA Intern Med. 2015 Aug;175(8):1412-3
pubmed: 26098405
Front Neuroendocrinol. 2016 Jan;40:101-9
pubmed: 26800649
J Neurosci. 2020 Mar 18;40(12):2519-2537
pubmed: 32054675
Nat Neurosci. 2011 Jun 05;14(7):911-8
pubmed: 21642975
Neuroendocrinology. 2013;98(1):60-72
pubmed: 23735696
Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1452-63
pubmed: 24148346
Int J Obes (Lond). 2019 Apr;43(4):928-932
pubmed: 30082747
J Comp Neurol. 2013 Oct 1;521(14):3167-90
pubmed: 23696474
J Neurosci. 2005 Mar 16;25(11):2933-40
pubmed: 15772353
Horm Behav. 1989 Jun;23(2):235-50
pubmed: 2663699
Eur J Biochem. 1992 Jul 1;207(1):239-46
pubmed: 1321043
Neuroendocrinology. 1998 Feb;67(2):73-82
pubmed: 9508037
Front Mol Neurosci. 2018 Jun 19;11:214
pubmed: 29973869
Front Neurosci. 2016 Aug 22;10:383
pubmed: 27597817
Appetite. 1991 Dec;17(3):167-75
pubmed: 1799279
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10673-8
pubmed: 21636788
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2726-31
pubmed: 11880626
Neurosci Biobehav Rev. 1996;20(1):1-25
pubmed: 8622814
Front Neurosci. 2019 Dec 12;13:1326
pubmed: 31920495
Eur J Pharmacol. 2009 Nov 10;622(1-3):15-24
pubmed: 19758570
Physiol Behav. 1999 Aug 1;67(1):141-7
pubmed: 10463640
Annu Rev Psychol. 2008;59:55-92
pubmed: 18154499
Curr Opin Psychiatry. 2006 Jul;19(4):389-94
pubmed: 16721169
Front Endocrinol (Lausanne). 2018 Oct 30;9:632
pubmed: 30425681
Endocrinology. 2010 Oct;151(10):4926-37
pubmed: 20685867
Neuron. 2006 Sep 21;51(6):801-10
pubmed: 16982424
Am J Physiol Regul Integr Comp Physiol. 2003 May;284(5):R1260-8
pubmed: 12521926
Mol Cancer Res. 2009 Jul;7(7):1132-8
pubmed: 19584261
Psychoneuroendocrinology. 2017 Apr;78:193-202
pubmed: 28214679

Auteurs

Nikki Le (N)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Jennifer Hernandez (J)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Cassandra Gastelum (C)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Lynnea Perez (L)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Isabella Vahrson (I)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Sarah Sayers (S)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Edward J Wagner (EJ)

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA. Electronic address: ewagner@westernu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Polypeptide activateur de l'adénylcyclase hypophysaire › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs au polypeptide activateur de l'adénylcyclase hypophysaire › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs au polypeptide activateur de l'adénylcyclase hypophysaire › Récepteur de type I au polypeptide activateur de l'adénylcyclase hypophysaire › Pituitary Adenylate Cyclase Activating...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Aire tegmentale ventrale › Pituitary Adenylate Cyclase Activating...