Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research.
Journal
Nature reviews. Rheumatology
ISSN: 1759-4804
Titre abrégé: Nat Rev Rheumatol
Pays: United States
ID NLM: 101500080
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
accepted:
27
08
2021
pubmed:
3
10
2021
medline:
16
11
2021
entrez:
2
10
2021
Statut:
ppublish
Résumé
Fatigue is a complex phenomenon and an important health concern for many people with chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, primary Sjögren syndrome and systemic lupus erythematosus. Although some clinical trials have shown the benefits of cognitive behavioural therapy in fatigue management, the effect of this approach is relatively modest, and no curative treatment has been identified. The pathogenesis of fatigue remains unclear. Despite many challenges and limitations, a growing body of research points to roles for the immune system, the central and autonomic nervous systems and the neuroendocrine system in the induction and maintenance of fatigue in chronic diseases. New insights indicate that sleep, genetic susceptibility, metabolic disturbances and other biological and physiological mechanisms contribute to fatigue. Furthermore, understanding of the relationships between psychosocial factors and fatigue is increasing. However, the interrelationships between these diverse mechanisms and fatigue remain poorly defined. In this Review, we outline various biological, physiological and psychosocial determinants of fatigue in inflammatory rheumatic diseases, and propose mechanistic and conceptual models of fatigue to summarize current understanding, stimulate debate and develop further research ideas.
Identifiants
pubmed: 34599320
doi: 10.1038/s41584-021-00692-1
pii: 10.1038/s41584-021-00692-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-664Subventions
Organisme : Medical Research Council
ID : G0800629
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J002720/1
Pays : United Kingdom
Informations de copyright
© 2021. Springer Nature Limited.
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