Possible association between SP-C mutations and lung cancer: Two case reports and review of literature.
Adenocarcinoma
Lung cancer
SP-C
Surfactant
Journal
Cancer treatment and research communications
ISSN: 2468-2942
Titre abrégé: Cancer Treat Res Commun
Pays: England
ID NLM: 101694651
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
08
2021
revised:
19
09
2021
accepted:
20
09
2021
pubmed:
3
10
2021
medline:
11
3
2022
entrez:
2
10
2021
Statut:
ppublish
Résumé
Surfactant protein C (SP-C) is one of four surfactant proteins produced by type II pneumocytes. Mutations in surfactant protein A are strongly associated with development of lung cancer. Mutations in the SP-C gene are rare and are associated with interstitial lung disease in the pediatric age group. We describe two patients with SP-C mutations who developed lung cancer. Both patients had concurrent interstitial lung disease, although the clinical phenotype was variable. In both cases, mutations were in translated region of the SP-C gene; one in the BRICHOS domain and the other in the transmembrane domain. Our paper suggests that patients with SP-C mutations can be at increased risk for the development of lung cancer, and it's reasonable to follow them routinely.
Identifiants
pubmed: 34600418
pii: S2468-2942(21)00157-X
doi: 10.1016/j.ctarc.2021.100461
pii:
doi:
Substances chimiques
Pulmonary Surfactant-Associated Protein C
0
SFTPC protein, human
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100461Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.