Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches.
Alzheimer’s disease
Cholinesterase’s
Cinnamon and GC-MS
Cumin
Free radicals
Functional foods
Ginger
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
02 Oct 2021
02 Oct 2021
Historique:
received:
12
01
2021
accepted:
22
09
2021
entrez:
3
10
2021
pubmed:
4
10
2021
medline:
31
12
2021
Statut:
epublish
Résumé
Edible oils have proven health benefits in the prevention and treatment of various disorders since the establishment of human era. This study was aimed to appraise neuropharmacological studies on the commonly used edible oils including Cinnamomum verum (CV), Zingiber officinale (ZO) and Cuminum cyminum (CC). The oils were analyzed via GC-MS for identifications of bioactive compounds. Anti-radicals capacity of the oils were evaluated via 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging assays. The samples were also tested against two important acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are among the important drug targets in Alzheimer's disease. Lineweaver-Burk plots were constructed for enzyme inhibition studies which correspond to velocity of enzymes (V (Gas chromatography-mass spectrometry GC-MS) analysis revealed the presence of thirty-four compounds in Cinnamon oil (Cv.Eo), fourteen in ginger oil (Zo.Eo) and fifty-six in cumin oil (Cc.Eo). In the antioxidant assays, Cv.Eo, Zo.Eo and Cc.Eo exhibited IC
Sections du résumé
BACKGROUND
BACKGROUND
Edible oils have proven health benefits in the prevention and treatment of various disorders since the establishment of human era. This study was aimed to appraise neuropharmacological studies on the commonly used edible oils including Cinnamomum verum (CV), Zingiber officinale (ZO) and Cuminum cyminum (CC).
METHODS
METHODS
The oils were analyzed via GC-MS for identifications of bioactive compounds. Anti-radicals capacity of the oils were evaluated via 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging assays. The samples were also tested against two important acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are among the important drug targets in Alzheimer's disease. Lineweaver-Burk plots were constructed for enzyme inhibition studies which correspond to velocity of enzymes (V
RESULTS
RESULTS
(Gas chromatography-mass spectrometry GC-MS) analysis revealed the presence of thirty-four compounds in Cinnamon oil (Cv.Eo), fourteen in ginger oil (Zo.Eo) and fifty-six in cumin oil (Cc.Eo). In the antioxidant assays, Cv.Eo, Zo.Eo and Cc.Eo exhibited IC
Identifiants
pubmed: 34600509
doi: 10.1186/s12906-021-03420-0
pii: 10.1186/s12906-021-03420-0
pmc: PMC8487577
doi:
Substances chimiques
Antioxidants
0
Enzyme Inhibitors
0
Neuroprotective Agents
0
Plant Oils
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
248Informations de copyright
© 2021. The Author(s).
Références
Front Biosci (Landmark Ed). 2017 Jan 1;22:732-756
pubmed: 27814643
Front Aging Neurosci. 2017 May 30;9:168
pubmed: 28611658
J Alzheimers Dis. 2009;17(3):585-97
pubmed: 19433898
Eur J Pharmacol. 2020 Apr 5;872:172972
pubmed: 32006559
J Biomol Struct Dyn. 2021 Feb;39(3):1044-1054
pubmed: 32013770
Mol Neurobiol. 2011 Oct;44(2):142-59
pubmed: 21360003
Bioorg Chem. 2019 Oct;91:103128
pubmed: 31369977
J Ethnopharmacol. 2020 Mar 1;249:112401
pubmed: 31739103
Steroids. 2019 Aug;148:56-62
pubmed: 31085212
Front Aging Neurosci. 2018 Oct 23;10:284
pubmed: 30405389
BMC Complement Altern Med. 2012 Dec 05;12:244
pubmed: 23217213
BMC Complement Altern Med. 2018 Jan 3;18(1):1
pubmed: 29295712
J Enzyme Inhib Med Chem. 2014 Oct;29(5):677-85
pubmed: 24102527
J Med Food. 2005 Summer;8(2):125-32
pubmed: 16117603
J Cancer Prev. 2017 Sep;22(3):127-134
pubmed: 29018777
Front Aging Neurosci. 2019 Jun 26;11:155
pubmed: 31293414
Bioorg Chem. 2019 Mar;83:336-347
pubmed: 30399465
J Biomol Struct Dyn. 2020 Nov;38(18):5488-5499
pubmed: 31838977
Biosci Biotechnol Biochem. 1996 Jan;60(1):9-15
pubmed: 8824819
Chem Biodivers. 2015 May;12(5):733-42
pubmed: 26010662
Front Pharmacol. 2018 Jun 13;9:623
pubmed: 29950997
BMC Complement Altern Med. 2014 Jun 03;14:181
pubmed: 24893601
Front Chem. 2020 Nov 26;8:558641
pubmed: 33335883
Bioorg Chem. 2018 Oct;80:99-111
pubmed: 29894893
Front Pharmacol. 2017 Oct 06;8:697
pubmed: 29056913
BMC Complement Altern Med. 2016 Jan 25;16:29
pubmed: 26810212
Front Pharmacol. 2021 Jan 27;11:580069
pubmed: 33584260
Eur J Med Chem. 2021 Jan 15;210:112986
pubmed: 33187806
Chem Cent J. 2015 May 26;9:31
pubmed: 26064188
Metab Brain Dis. 2021 Jun;36(5):889-900
pubmed: 33570733
Front Pharmacol. 2016 Mar 31;7:74
pubmed: 27065865
Nutr Cancer. 1992;18(1):1-29
pubmed: 1408943
Biol Res. 2014 Dec 26;47:76
pubmed: 25723481
Pak J Pharm Sci. 2015 Jan;28(1):23-8
pubmed: 25553682
BMC Complement Altern Med. 2016 Nov 24;16(1):478
pubmed: 27881119
Drug Des Devel Ther. 2020 Jun 03;14:2165-2178
pubmed: 32606589
Biosens Bioelectron. 1999 Jan 1;14(1):9-18
pubmed: 10028645
Biol Res. 2016 Mar 12;49:18
pubmed: 26969307
BMC Biochem. 2018 Jun 26;19(1):5
pubmed: 29940844
Bioorg Chem. 2017 Jun;72:256-267
pubmed: 28495556
Front Chem. 2018 Mar 12;6:55
pubmed: 29594100
BMC Complement Altern Med. 2013 Oct 22;13:275
pubmed: 24148965
Nat Prod Res. 2016 Jun;30(12):1440-4
pubmed: 26166432
J Ethnopharmacol. 1989 Nov;27(1-2):129-40
pubmed: 2615416
Front Chem. 2017 Aug 02;5:58
pubmed: 28824906
Steroids. 2020 Jun;158:108599
pubmed: 32126219
Front Pharmacol. 2019 Nov 26;10:1417
pubmed: 31849668
Food Chem Toxicol. 2018 Sep;119:407-416
pubmed: 29288755
Semin Cancer Biol. 2021 Jun 9;:
pubmed: 34118405
Medicina (Kaunas). 2019 May 22;55(5):
pubmed: 31121979