Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia.
catheter ablation
histology
immunohistochemistry
radiotherapy
ventricular tachycardia
Journal
JACC. Clinical electrophysiology
ISSN: 2405-5018
Titre abrégé: JACC Clin Electrophysiol
Pays: United States
ID NLM: 101656995
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
05
05
2021
revised:
26
07
2021
accepted:
26
07
2021
pubmed:
4
10
2021
medline:
3
2
2022
entrez:
3
10
2021
Statut:
ppublish
Résumé
Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects.
Identifiants
pubmed: 34600851
pii: S2405-500X(21)00687-3
doi: 10.1016/j.jacep.2021.07.012
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1487-1492Informations de copyright
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support and Author Disclosures This work was supported by grant project AZV NU20-02-00244 from the Ministry of Health of the Czech Republic and by funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 945119. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.