SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France.

COVID-19 COVID-19 Testing Humans Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 14 05 2021
revised: 14 09 2021
accepted: 27 09 2021
pubmed: 4 10 2021
medline: 15 12 2021
entrez: 3 10 2021
Statut: ppublish

Résumé

SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values.

Identifiants

DOI: 10.1016/j.ijid.2021.09.076 PMID: 34601145 PMC: PMC8484004
pubmed: 34601145
pii: S1201-9712(21)00784-0
doi: 10.1016/j.ijid.2021.09.076
pmc: PMC8484004
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-14

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Benedicte Roquebert (B)

Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.

Stéphanie Haim-Boukobza (S)

Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.

Sabine Trombert-Paolantoni (S)

Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.

Emmanuel Lecorche (E)

Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.

Laura Verdurme (L)

Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.

Vincent Foulongne (V)

Laboratoire de Virologie, CHU de Montpellier - 80 av Augustin Fliche, Montpellier 34295, France.

Sonia Burrel (S)

Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), AP-HP, Hôpital Pitié-Salpêtriére, Service de Virologie - 47-83 bd de l'Hôpital, Paris 75013, France.

Samuel Alizon (S)

MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France.

Mircea T Sofonea (MT)

MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France. Electronic address: mircea.sofonea@umontpellier.fr.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › SARS-CoV-2 variants of concern are associated...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Dépistage de la COVID-19 › SARS-CoV-2 variants of concern are associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SARS-CoV-2 variants of concern are associated...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Réaction de polymérisation en chaîne › RT-PCR › SARS-CoV-2 variants of concern are associated...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › SARS-CoV-2 variants of concern are associated...