Heritable Thoracic Aortic Aneurysms and Dissections.

Aortic Dissection / diagnostic imaging Aortic Aneurysm, Thoracic / diagnostic imaging Dissection Humans
Clinical evaluation Genetic evaluation Genetics Inheritable thoracic aortic aneurysm and dissection management

Journal

Techniques in vascular and interventional radiology
ISSN: 1557-9808
Titre abrégé: Tech Vasc Interv Radiol
Pays: United States
ID NLM: 9806675

Informations de publication

Date de publication:
Jun 2021
Historique:
entrez: 4 10 2021
pubmed: 5 10 2021
medline: 29 10 2021
Statut: ppublish

Résumé

A large portion of thoracic aortic aneurysms and dissections (TAAD) have a genetic etiology. In recent decades, numerous genes have been identified as associated with heritable thoracic aortic aneurysms and dissections (HTAAD), providing important insights into the underlying molecular mechanisms of both conditions. Today's sequencing technology has allowed us to screen people with high risk of HTAAD, and provide gene‑tailored treatment and management. This review aims to provide an overview of the genetic basis of HTAAD, its underlying molecular mechanism, and practical recommendations for genetic and clinical evaluation as well as patient management.

Identifiants

DOI: 10.1016/j.tvir.2021.100747 PMID: 34602273
pubmed: 34602273
pii: S1089-2516(21)00028-7
doi: 10.1016/j.tvir.2021.100747
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100747

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Tingting Huang (T)

Department of Cardiac Surgery, North Campus Research Complex, University of Michigan, Ann Arbor, MI; Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.

Bo Yang (B)

Department of Cardiac Surgery, North Campus Research Complex, University of Michigan, Ann Arbor, MI. Electronic address: boya@med.umich.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies de l'aorte › Syndrome aortique aigu › Dissection aortique › Heritable Thoracic Aortic Aneurysms and Dissections.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies de l'aorte › Anévrysme de l'aorte › Anévrysme de l'aorte thoracique › Heritable Thoracic Aortic Aneurysms and Dissections.
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Manipulation d'échantillons › Dissection › Heritable Thoracic Aortic Aneurysms and Dissections.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Heritable Thoracic Aortic Aneurysms and Dissections.