Serum biomarkers for chronic pancreatitis pain patterns.
Chronic pancreatitis
Pain biomarkers
Pain frequency
Pain severity
Serum
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
08
06
2021
revised:
15
09
2021
accepted:
25
09
2021
pubmed:
5
10
2021
medline:
1
3
2022
entrez:
4
10
2021
Statut:
ppublish
Résumé
Chronic pancreatitis (CP) is associated with debilitating refractory pain. Distinct subtypes of CP pain have been previously characterized based on severity (none, mild-moderate, severe) and temporal (none, intermittent, constant) nature of pain, but no mechanism-based tools are available to guide pain management. This exploratory study was designed to determine if potential pain biomarkers could be detected in patient serum and whether they associate with specific pain patterns. Cytokines, chemokines, and peptides associated with nociception and pain were measured in legacy serum samples from CP patients (N = 99) enrolled in the North American Pancreatitis Studies. The unsupervised hierarchical cluster analysis was applied to cluster CP patients based on their biomarker profile. Classification and regression tree was used to assess whether these biomarkers can predict pain outcomes. The hierarchical cluster analysis revealed a subset of patients with predominantly constant, mild-moderate pain exhibited elevated interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-2 (IL-2), tumor necrosis factor alpha (TNFα), and monocyte chemoattractant protein-1 (MCP1) whereas patients with higher interleukin-4 (IL-4), interleukin-8 (IL-8) and calcitonin gene related peptide (CGRP) were more likely to have severe pain. Interestingly, analyses of each individual biomarker revealed that patients with constant pain had reduced circulating TNFα and fractalkine. Patients with severe pain exhibited a significant reduction in TNFα as well as trends towards lower levels of IL-6 and substance P. The observations from this study indicate that unique pain experiences within the chronic pancreatitis population can be associated with distinct biochemical signatures. These data indicate that further hypothesis-driven analyses combining biochemical measurements and detailed pain phenotyping could be used to develop precision approaches for pain management in patients with chronic pancreatitis.
Identifiants
pubmed: 34602367
pii: S1424-3903(21)00580-9
doi: 10.1016/j.pan.2021.09.016
pmc: PMC8629935
mid: NIHMS1745371
pii:
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1411-1418Subventions
Organisme : NIDDK NIH HHS
ID : R56 DK061451
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK122293
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK120737
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK108306
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK061451
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK077906
Pays : United States
Informations de copyright
Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.
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