The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas.
Pleomorphic adenoma
carcinoma ex pleomorphic adenoma
herpesvirus
recurrent pleomorphic adenoma
viral etiology
Journal
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
ISSN: 1423-0380
Titre abrégé: Tumour Biol
Pays: Netherlands
ID NLM: 8409922
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
13
10
2021
Statut:
ppublish
Résumé
The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background. This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA). Thirty different viruses were analyzed by PCR-based assays in 68 formalin-fixed paraffin-embedded salivary gland tumors (25 PA, 31 RPA and 12 CaxPA). Virus DNA was detected altogether in 19/68 (28%) tumor samples. Human herpesviruses 6B and 7 (HHV-6B and HHV-7) and Epstein-Barr virus (EBV) were frequently and almost exclusively found in CaxPA (5/12, 7/12, and 3/12, respectively). Within the 7 CaxPA that were virus-positive, 3 samples contained 3, and 1 sample even 4, different viruses. Infrequent viral positivity was shown for parvovirus B19 and cutavirus, as well as Merkel cell and Malawi polyomaviruses. Our unexpected finding of herpesvirus DNA almost exclusively in CaxPA tissues deserves further in-depth studies.
Sections du résumé
BACKGROUND
BACKGROUND
The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background.
OBJECTIVE
OBJECTIVE
This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA).
METHODS
METHODS
Thirty different viruses were analyzed by PCR-based assays in 68 formalin-fixed paraffin-embedded salivary gland tumors (25 PA, 31 RPA and 12 CaxPA).
RESULTS
RESULTS
Virus DNA was detected altogether in 19/68 (28%) tumor samples. Human herpesviruses 6B and 7 (HHV-6B and HHV-7) and Epstein-Barr virus (EBV) were frequently and almost exclusively found in CaxPA (5/12, 7/12, and 3/12, respectively). Within the 7 CaxPA that were virus-positive, 3 samples contained 3, and 1 sample even 4, different viruses. Infrequent viral positivity was shown for parvovirus B19 and cutavirus, as well as Merkel cell and Malawi polyomaviruses.
CONCLUSIONS
CONCLUSIONS
Our unexpected finding of herpesvirus DNA almost exclusively in CaxPA tissues deserves further in-depth studies.
Identifiants
pubmed: 34602506
pii: TUB211519
doi: 10.3233/TUB-211519
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM