Sinus venous thrombosis as a complication of COVID-19-associated hypercoagulability.
COVID-19
Complications
Hypercoagulability
SARS-CoV-2
Thrombosis
Journal
The Egyptian journal of neurology, psychiatry and neurosurgery
ISSN: 1110-1083
Titre abrégé: Egypt J Neurol Psychiatr Neurosurg
Pays: England
ID NLM: 0043617
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
07
2021
accepted:
08
09
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
ppublish
Résumé
Sinus venous thrombosis (SVT) is an increasingly recognised complication of not only SARS-CoV-2 infections, but also of SARS-CoV-2 vaccinations. SVT is attributed to hypercoagulability, a common complication of COVID-19, disregarding the severity of the infection. Hypercoagulability in COVID-19 is explained by direct activation of platelets, enhancing coagulation, by direct infection and indirect activation of endothelial cells by SARS-CoV-2, shifting endothelial cells from an anti-thrombotic to a pro-thrombotic state, by direct activation of complement pathways, promoting thrombin generation, or by immune thrombocytopenia, which also generates a thrombogenic state. Since SVT may occur even in anticoagulated COVID-19 patients and may have an unfavourable outcome, all efforts must be made to prevent this complication or to treat it accurately.
Identifiants
pubmed: 34602810
doi: 10.1186/s41983-021-00387-0
pii: 387
pmc: PMC8475476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
132Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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