Follicular Helper T Cells in the Immunopathogenesis of SARS-CoV-2 Infection.
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Antibody Formation
/ immunology
B-Lymphocytes
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Cell Differentiation
/ immunology
Germinal Center
/ cytology
Humans
Lymphocyte Activation
/ immunology
SARS-CoV-2
/ immunology
T Follicular Helper Cells
/ cytology
B cells
COVID-19
SARS-CoV-2
Tfh cells
neutralizing antibody
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
06
2021
accepted:
01
09
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a global pandemic with high morbidity and mortality. High-affinity neutralizing antibody is important for controlling infection, which is closely regulated by follicular helper T (Tfh) cells. Tfh cells play a central role in promoting germinal center reactions and driving cognate B cell differentiation for antibody secretion. Available studies indicate a close relationship between virus-specific Tfh cell-mediated immunity and SARS-CoV-2 infection progression. Although several lines of evidence have suggested that Tfh cells contribute to the control of SARS-CoV-2 infection by eliciting neutralizing antibody productions, further studies are needed to elucidate Tfh-mediated effector mechanisms in anti-SARS-CoV-2 immunity. Here, we summarize the functional features and roles of virus-specific Tfh cells in the immunopathogenesis of SARS-CoV-2 infection and in COVID-19 vaccines, and highlight the potential of targeting Tfh cells as therapeutic strategy against SARS-CoV-2 infection.
Identifiants
pubmed: 34603308
doi: 10.3389/fimmu.2021.731100
pmc: PMC8481693
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
731100Informations de copyright
Copyright © 2021 Cui, Tang, Jiang, Jiang, Zhang, Lv, Xu, Wu, Xie, Wen and Lu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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