Fecal microbiota transplants: A review of emerging clinical data on applications, efficacy, and risks (2015-2020).
Clostridium difficile
Fecal transplant
Qatar
antibiotic resistance
clinical trial
microbiota
Journal
Qatar medical journal
ISSN: 0253-8253
Titre abrégé: Qatar Med J
Pays: Qatar
ID NLM: 8101648
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
05
2020
accepted:
07
07
2020
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
As the importance of the gut microbiota in health and disease is a subject of growing interest, fecal microbiota transplantation (FMT) was suggested as an attractive therapeutic strategy to restore homeostasis of the gut microbiota, thereby treating diseases that were associated with alteration of the gut microbiota. FMT involves the administration of fresh, frozen, or dried fecal microorganisms from the gut of a healthy donor into the intestinal tract of a patient. This rediscovery of the potential benefits of an ancient practice was accompanied by a rapid progression of our understanding of the roles and mechanisms of gut microbes in the pathogenesis of disease. With a growing number of diseases being associated with dysbiosis or the alteration of gut microbiota, FMT was suggested as an attractive therapeutic strategy to "reset the gut" and initiate clinical resolutions or remissions. The number of FMT clinical trials is increasing worldwide, but no trials are registered in the Gulf region; this suggested the need for raising awareness of the latest studies on FMT. This review presented the emergent preclinical and clinical data to give an overview of the potential clinical applications, the benefits, and inconveniences that were worth considering for eventual future testing of fecal transplants in Qatar and the Middle East. This study highlighted the diversity of methods tested and commented on the variables that can affect the assessment of the effectiveness of FMT in specific diseases. The risks associated with FMT and the threat of antimicrobial resistance for this therapeutic approach were reviewed. From gastrointestinal diseases to neurodevelopmental disorders, understanding the roles of the gut microbiota in health and disease should be at the heart of developing novel, standardized, yet personalized, methods for this ancient therapeutic approach.
Identifiants
pubmed: 34604008
doi: 10.5339/qmj.2021.5
pii: qmj.2021.5
pmc: PMC8475724
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5Informations de copyright
© 2021 Al-Ali, Ahmed, Shafiq, McVeigh, Chaari, Zakaria, Bendriss, licensee HBKU Press.
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