Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth.
B16 engraftment
TIL (tumor infiltrating lymphocytes)
UDP
anti-tumor immunity
metabolite profiling
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
06
2021
accepted:
26
08
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific metabolites, accumulated within the TIF, could induce metabolic alterations of immune cells and shape the tumor microenvironment. We deployed a metabolomic approach to analyze the composition of melanoma TIF and compared it to the plasma of C57BL6 mice, engrafted or not with B16-melanoma cells. Among the classes of metabolites analyzed, monophosphate and diphosphate nucleotides resulted enriched in TIF compared to plasma samples. The analysis of the effects exerted by guanosine diphosphate (GDP) and uridine diphosphate (UDP) on immune response revealed that GDP and UDP increased the percentage of CD4
Identifiants
pubmed: 34604232
doi: 10.3389/fcell.2021.730726
pmc: PMC8486041
doi:
Types de publication
Journal Article
Langues
eng
Pagination
730726Informations de copyright
Copyright © 2021 Vecchio, Caiazza, Mimmi, Avagliano, Iaccino, Brusco, Nisticò, Maisano, Aloisio, Quinto, Renna, Divisato, Romano, Tufano, D’Agostino, Vigliar, Iaccarino, Mignogna, Andreozzi, Mannino, Spiga, Stornaiuolo, Arcucci, Mallardo and Fiume.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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