Wild-Type p53-Induced Phosphatase 1 Plays a Positive Role in Hematopoiesis in the Mouse Embryonic Head.
Wip1
embryonic head
hematopoietic stem cell
microglia
pro-inflammatory factor
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
06
2021
accepted:
18
08
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
The first adult repopulating hematopoietic stem cells (HSCs) are found in the aorta-gonad-mesonephros (AGM) region, which are produced from hemogenic endothelial cells. Embryonic head is the other site for HSC development. Wild-type p53-induced phosphatase 1 (Wip1) is a type-2Cδ family serine/threonine phosphatase involved in various cellular processes such as lymphoid development and differentiation of adult HSCs. Most recently, we have shown that Wip1 modulates the pre-HSC maturation in the AGM region. However, it is not clear whether Wip1 regulates hematopoiesis in the embryonic head. Here we reported that disruption of Wip1 resulted in a decrease of hematopoietic progenitor cell number in the embryonic head.
Identifiants
pubmed: 34604235
doi: 10.3389/fcell.2021.732527
pmc: PMC8484912
doi:
Types de publication
Journal Article
Langues
eng
Pagination
732527Informations de copyright
Copyright © 2021 He, Zhang, Cao, Ye, Lu, Fan, Peng and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Stem Cells. 2016 Feb;34(2):431-44
pubmed: 26418893
Blood. 2020 Aug 13;136(7):831-844
pubmed: 32457985
Blood. 2013 Jan 17;121(3):519-29
pubmed: 23212517
Cancer Biol Ther. 2005 Oct;4(10):1154-8
pubmed: 16258255
Haematologica. 2021 Feb 01;106(2):580-584
pubmed: 32107340
Nat Commun. 2015 Apr 16;6:6808
pubmed: 25879755
Cell Res. 2020 Jun;30(6):457-458
pubmed: 32398861
Nature. 2016 May 18;533(7604):487-92
pubmed: 27225119
Nature. 2015 Feb 26;518(7540):547-51
pubmed: 25470051
Stem Cell Reports. 2014 Sep 9;3(3):489-501
pubmed: 25241746
Cell Death Discov. 2017 Apr 03;3:17018
pubmed: 28417018
J Immunol. 2014 Feb 1;192(3):1184-95
pubmed: 24395919
Blood. 2019 Nov 28;134(22):1929-1940
pubmed: 31697805
Immunity. 2019 Jun 18;50(6):1439-1452.e5
pubmed: 31178352
Nature. 2009 Feb 12;457(7231):887-91
pubmed: 19129762
Cell Stem Cell. 2007 Aug 16;1(2):180-90
pubmed: 18371349
Cell Stem Cell. 2018 May 3;22(5):639-651
pubmed: 29727679
Arch Pharm Res. 2010 Aug;33(8):1253-60
pubmed: 20803129
Genes Dev. 2014 Dec 1;28(23):2597-612
pubmed: 25395663
Immunity. 1994 Jul;1(4):291-301
pubmed: 7889417
Blood. 2015 Jul 30;126(5):620-8
pubmed: 26012568
Cell Rep. 2015 Jun 30;11(12):1892-904
pubmed: 26095363
Stem Cells. 2009 Jun;27(6):1433-42
pubmed: 19489034
PLoS One. 2016 May 26;11(5):e0156427
pubmed: 27227884
Cell Res. 2020 May;30(5):376-392
pubmed: 32203131
J Exp Med. 2011 Jun 6;208(6):1305-15
pubmed: 21624936
Mol Cell Biol. 2002 Feb;22(4):1094-105
pubmed: 11809801
Nat Rev Immunol. 2018 Apr;18(4):225-242
pubmed: 29151590
Cell Stem Cell. 2012 Nov 2;11(5):663-75
pubmed: 23122290
Dev Biol. 2016 Aug 1;416(1):34-41
pubmed: 27235813
Cell Stem Cell. 2008 Jul 3;3(1):99-108
pubmed: 18593562
Immunity. 2015 Apr 21;42(4):665-78
pubmed: 25902481
J Exp Med. 2015 Jan 12;212(1):93-106
pubmed: 25547674