Multifrequency STD NMR Unveils the Interactions of Antibiotics With
Burkholderia multivorans
STD NMR
biofilms
exopolysaccharides
multifrequency STD NMR
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
06
2021
accepted:
02
08
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Biofilms confine bacterial cells within self-produced matrices, offering advantages such as protection from antibiotics and entrapment of nutrients. Polysaccharides are major components in these macromolecular assemblies, and their interactions with other chemicals are of high relevance for the benefits provided by the biofilm 3D molecular matrix. NMR is a powerful technique for the study and characterization of the interactions between molecules of biological relevance. In this study, we have applied multifrequency saturation transfer difference (STD) NMR and DOSY NMR approaches to elucidate the interactions between the exopolysaccharide produced by
Identifiants
pubmed: 34604306
doi: 10.3389/fmolb.2021.727980
pii: 727980
pmc: PMC8481691
doi:
Types de publication
Journal Article
Langues
eng
Pagination
727980Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM123283
Pays : United States
Informations de copyright
Copyright © 2021 Nepravishta, Monaco, Distefano, Rizzo, Cescutti and Angulo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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