Multidimensional Mechanistic Spectrum of Long Non-coding RNAs in Heart Development and Disease.
PRC2 complex
ceRNA
heart development
heart disease
long non-coding RNA
microRNA
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
06
2021
accepted:
16
08
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
With the large-scale genome-wide sequencing, long non-coding RNAs (lncRNAs) have been found to compose of a large portion of the human transcriptome. Recent studies demonstrated the multidimensional functions of lncRNAs in heart development and disease. The subcellular localization of lncRNA is considered as a key factor that determines lncRNA function. Cytosolic lncRNAs mainly regulate mRNA stability, mRNA translation, miRNA processing and function, whereas nuclear lncRNAs epigenetically regulate chromatin remodeling, structure, and gene transcription. In this review, we summarize the molecular mechanisms of cytosolic and nuclear lncRNAs in heart development and disease separately, and emphasize the recent progress to dictate the crosstalk of cytosolic and nuclear lncRNAs in orchestrating the same biological process. Given the low evolutionary conservation of most lncRNAs, deeper understanding of human lncRNA will uncover a new layer of human regulatory mechanism underlying heart development and disease, and benefit the future clinical treatment for human heart disease.
Identifiants
pubmed: 34604357
doi: 10.3389/fcvm.2021.728746
pmc: PMC8483262
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
728746Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL147871
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD095049
Pays : United States
Informations de copyright
Copyright © 2021 Han and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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