COVID-19 patients and Dementia: Frontal cortex transcriptomic data.

Brain Gene expression SARS-CoV-2 Transcriptomics

Journal

Data in brief
ISSN: 2352-3409
Titre abrégé: Data Brief
Pays: Netherlands
ID NLM: 101654995

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 03 06 2021
revised: 18 09 2021
accepted: 23 09 2021
entrez: 4 10 2021
pubmed: 5 10 2021
medline: 5 10 2021
Statut: ppublish

Résumé

Since the association of SARS-Cov-2 infection with Nervous System (NS) manifestations, we performed RNA-sequencing analysis in Frontal Cortex of COVID-19 positive or negative individuals and affected or not by Dementia individuals. We examined gene expression differences in individuals with COVID-19 and Dementia compared to Dementia only patients by collecting transcript counts in each sample and performing Differential Expression analysis. We found eleven genes satisfying our significance criteria, all of them being protein coding genes. These data are suitable for integration with supplemental samples and for analysis according to different individuals' classification. Also, differential expression evaluation may be implemented with other scientific purposes, such as research of unannotated genes, mRNA splicing and genes isoforms. The analysis of Differential Expressed genes in COVID-19 positive patients compared to non-COVID-19 patients is published in: S. Gagliardi, E.T. Poloni, C. Pandini, M. Garofalo, F. Dragoni, V. Medici, A. Davin, S.D. Visonà, M. Moretti, D. Sproviero, O. Pansarasa, A. Guaita, M. Ceroni, L. Tronconi, C. Cereda, Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients., Brain. Behav. Immun. (2021). https://doi.org/10.1016/j.bbi.2021.05.012.

Identifiants

pubmed: 34604485
doi: 10.1016/j.dib.2021.107432
pii: S2352-3409(21)00714-9
pmc: PMC8479506
doi:

Types de publication

Journal Article

Langues

eng

Pagination

107432

Informations de copyright

© 2021 Published by Elsevier Inc.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships which have or could be perceived to have influenced the work reported in this article.

Références

Genome Res. 2017 Mar;27(3):491-499
pubmed: 28100584
Brain Behav Immun. 2021 Oct;97:13-21
pubmed: 34022369

Auteurs

Maria Garofalo (M)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Stella Gagliardi (S)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.

Susanna Zucca (S)

EnGenome SRL, Pavia 27100, Italy.

Cecilia Pandini (C)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.

Francesca Dragoni (F)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Daisy Sproviero (D)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.

Orietta Pansarasa (O)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.

Tino Emanuele Poloni (TE)

Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy.

Valentina Medici (V)

Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy.

Annalisa Davin (A)

Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy.

Silvia Damiana Visonà (SD)

Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences "A. Fornari", University of Pavia, Pavia, Italy.

Matteo Moretti (M)

Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences "A. Fornari", University of Pavia, Pavia, Italy.

Antonio Guaita (A)

Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy.

Mauro Ceroni (M)

Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Department of General Neurology, IRCCS Mondino Foundation, Pavia, Italy.

Livio Tronconi (L)

Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences "A. Fornari", University of Pavia, Pavia, Italy.
U.O. Medicina Legale, IRCCS Mondino Foundation, Pavia, Italy.

Cristina Cereda (C)

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.

Classifications MeSH