Ablation of liver
BAs, bile acids
Colon
DSS, dextran sodium sulfate
FITC, fluorescein isothiocyanate
Farnesoid X receptor
Fgfr4, fibroblast growth factor receptor 4
Fxr, farnesoid X receptor
Fxr-intKO, intestine-specific Fxr knockout
Fxr-livKO, liver-specific Fxr knockout
Fxr-totKO, whole body Fxr knockout
GO, Gene Ontology
Gut microbiome
HID, high-iron diamine
IBD, inflammatory bowel disease
Intestine-specific Fxr-KO mouse
KEGG, Kyoto Encyclopedia of Genes and Genomes
Liver-specific Fxr-KO mouse
Liver–gut axis
Mucus layer
RT qPCR, real-time quantitative PCR
fpkm, fragments per kilobase of transcript per million mapped reads
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
01
06
2021
revised:
16
07
2021
accepted:
22
07
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
5
10
2021
Statut:
epublish
Résumé
The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon absorption reach back to the liver. The bile acid-activated farnesoid X receptor ( Fxr floxed/floxed mice were crossed with cre-expressing mice to yield Despite relatively small changes in biliary bile acid concentration and composition, more genes were differentially expressed in the colons of Targeting of This study shows that the communication of the liver to the intestine is crucial for intestinal health. Bile acids are key players in this liver-to-gut communication, and when
Sections du résumé
BACKGROUND & AIMS
OBJECTIVE
The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon absorption reach back to the liver. The bile acid-activated farnesoid X receptor (
METHODS
METHODS
Fxr floxed/floxed mice were crossed with cre-expressing mice to yield
RESULTS
RESULTS
Despite relatively small changes in biliary bile acid concentration and composition, more genes were differentially expressed in the colons of
CONCLUSIONS
CONCLUSIONS
Targeting of
LAY SUMMARY
BACKGROUND
This study shows that the communication of the liver to the intestine is crucial for intestinal health. Bile acids are key players in this liver-to-gut communication, and when
Identifiants
pubmed: 34604725
doi: 10.1016/j.jhepr.2021.100344
pii: S2589-5559(21)00120-8
pmc: PMC8463863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100344Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
Authors declare no conflict of interest, except for RP, CEO at TES Pharma; CC, employed by TESS Pharma; and SY, currently working at Janssen Pharmaceuticals. Please refer to the accompanying ICMJE disclosure forms for further details.
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