Genetic discovery and risk characterization in type 2 diabetes across diverse populations.

Journal

HGG advances
ISSN: 2666-2477
Titre abrégé: HGG Adv
Pays: United States
ID NLM: 101772885

Informations de publication

Date de publication:
08 Apr 2021
Historique:
entrez: 4 10 2021
pubmed: 5 10 2021
medline: 5 10 2021
Statut: ppublish

Résumé

Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, and European population groups in the Population Architecture Genomics and Epidemiology (PAGE) and Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortia. In individuals of African ancestry, we discovered a risk variant in the

Identifiants

DOI: 10.1016/j.xhgg.2021.100029 PMID: 34604815 PMC: PMC8486151
pubmed: 34604815
doi: 10.1016/j.xhgg.2021.100029
pmc: PMC8486151
mid: NIHMS1691705
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM133169
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142302
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NHGRI NIH HHS
ID : R56 HG010297
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124097
Pays : United States
Organisme : BLRD VA
ID : I01 BX005831
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL135405
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG011723
Pays : United States
Organisme : CSRD VA
ID : I01 CX001737
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010297
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States

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Auteurs

Linda M Polfus (LM)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
These authors contributed equally.

Burcu F Darst (BF)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
These authors contributed equally.

Heather Highland (H)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Xin Sheng (X)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.

Maggie C Y Ng (MCY)

Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

Jennifer E Below (JE)

The Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

Lauren Petty (L)

The Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

Stephanie Bien (S)

Adaptive Biotechnologies Corporation, Seattle, WA, USA.

Xueling Sim (X)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Wei Wang (W)

23andMe, Sunnyvale, CA, USA.

Pierre Fontanillas (P)

23andMe, Sunnyvale, CA, USA.

Yesha Patel (Y)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.

Michael Preuss (M)

Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.

Claudia Schurmann (C)

Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.

Zhaohui Du (Z)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.

Yingchang Lu (Y)

Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

Suhn K Rhie (SK)

Department of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA, USA.

Joseph M Mercader (JM)

Program in Metabolism, Broad Institute, Cambridge, MA, USA.

Teresa Tusie-Luna (T)

Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico.

Clicerio González-Villalpando (C)

Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico.

Lorena Orozco (L)

Instituto Nacional de Medicina Genómica, Mexico City, Mexico.

Cassandra N Spracklen (CN)

Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA.

Brian E Cade (BE)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.

Richard A Jensen (RA)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.

Meng Sun (M)

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, USA.

Yoonjung Yoonie Joo (YY)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Ping An (P)

Division of Statistical Genomics, School of Medicine, Washington University, St. Louis, MO, USA.

Lisa R Yanek (LR)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Lawrence F Bielak (LF)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Salman Tajuddin (S)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

Aude Nicolas (A)

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

Guanjie Chen (G)

Center for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.

Laura Raffield (L)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Xiuqing Guo (X)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Wei-Min Chen (WM)

Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Girish N Nadkarni (GN)

Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.

Mariaelisa Graff (M)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Ran Tao (R)

Department of Biostatistics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.

James S Pankow (JS)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Martha Daviglus (M)

Institute for Minority Health Research, University of Illinois Chicago, Chicago, IL, USA.

Qibin Qi (Q)

Center for Population Cohorts, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Eric A Boerwinkle (EA)

Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.

Simin Liu (S)

School of Public Health, Brown University, Providence, RI, USA.

Lawrence S Phillips (LS)

Atlanta VA Medical Center, Decatur, GA, USA.
Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Ulrike Peters (U)

Division of Public Health Sciences, University of Washington, Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Chris Carlson (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Lynne R Wikens (LR)

University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.

Loic Le Marchand (LL)

University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.

Kari E North (KE)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Steven Buyske (S)

Department of Statistics, Rutgers University, Piscataway, NJ, USA.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Ruth J F Loos (RJF)

Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.

Daniel O Stram (DO)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.

Christopher A Haiman (CA)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.

Classifications MeSH