A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus.
DNA gyrase
EC/11716
Mycobacterium abscessus
Mycobacterium tuberculosis gyrase inhibitor
nontuberculous mycobacteria
novel bacterial topoisomerase inhibitor
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
17 11 2021
17 11 2021
Historique:
pubmed:
5
10
2021
medline:
15
12
2021
entrez:
4
10
2021
Statut:
ppublish
Résumé
Fluoroquinolones-the only clinically used DNA gyrase inhibitors-are effective against tuberculosis (TB) but are in limited clinical use for nontuberculous mycobacteria (NTM) lung infections due to intrinsic drug resistance. We sought to test alternative DNA gyrase inhibitors for anti-NTM activity. Mycobacterium tuberculosis gyrase inhibitors (MGIs), a subclass of novel bacterial topoisomerase inhibitors (NBTIs), were recently shown to be active against the tubercle bacillus. Here, we show that the MGI EC/11716 not only has potent anti-tubercular activity but is active against M. abscessus and M. avium
Identifiants
pubmed: 34606340
doi: 10.1128/AAC.01514-21
pmc: PMC8597734
doi:
Substances chimiques
Topoisomerase II Inhibitors
0
Thioinosine
46S541971T
4-nitrobenzylthioinosine
GV1L2DZM2Z
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0151421Subventions
Organisme : NIAID NIH HHS
ID : R01 AI132374
Pays : United States
Organisme : NIH HHS
ID : S10 OD023524
Pays : United States
Organisme : Cystic Fibrosis Foundation (CFF)
ID : DICK17XX00
Organisme : HHS | National Institutes of Health (NIH)
ID : R01AI132374
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