Y chromosome functions in mammalian spermatogenesis.
Y chromosome
developmental biology
fertility
spermatogenesis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 10 2021
04 10 2021
Historique:
received:
09
02
2021
accepted:
09
09
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
30
1
2022
Statut:
epublish
Résumé
The mammalian Y chromosome is critical for male sex determination and spermatogenesis. However, linking each Y gene to specific aspects of male reproduction has been challenging. As the Y chromosome is notoriously hard to sequence and target, functional studies have mostly relied on transgene-rescue approaches using mouse models with large multi-gene deletions. These experimental limitations have oriented the field toward the search for a minimum set of Y genes necessary for male reproduction. Here, considering Y-chromosome evolutionary history and decades of discoveries, we review the current state of research on its function in spermatogenesis and reassess the view that many Y genes are disposable for male reproduction.
Identifiants
pubmed: 34606444
doi: 10.7554/eLife.67345
pii: 67345
pmc: PMC8489898
doi:
pii:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : FC001193
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001193
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001193
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001193
Pays : United Kingdom
Informations de copyright
© 2021, Subrini and Turner.
Déclaration de conflit d'intérêts
JS, JT No competing interests declared
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