Transcriptional regulation of HIF1α-mediated STAR expression in murine KK1 granulosa cell line involves cJUN, CREB and CBP-dependent pathways.

Animals CREB-Binding Protein / metabolism Cyclic AMP Response Element-Binding Protein / genetics Female Gene Expression Regulation Granulosa Cells / metabolism Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Metabolic Networks and Pathways Mice Phosphoproteins / genetics Proto-Oncogene Proteins c-jun / metabolism
CREB Granulosa cells HIF1α STAR Transcriptional regulation cJUN

Journal

General and comparative endocrinology
ISSN: 1095-6840
Titre abrégé: Gen Comp Endocrinol
Pays: United States
ID NLM: 0370735

Informations de publication

Date de publication:
01 01 2022
Historique:
received: 07 04 2021
revised: 09 09 2021
accepted: 29 09 2021
pubmed: 5 10 2021
medline: 17 3 2022
entrez: 4 10 2021
Statut: ppublish

Résumé

Gonadal function is connected to hypoxia, with hypoxia-inducible factor (HIF) 1α, as a component of HIF1-complexes, regulating cellular adaptation to hypoxic conditions. In the ovary, it regulates follicular maturation, ovulation and luteal development. At the cellular level, HIF1-complexes coordinate the expression of steroidogenic acute regulatory protein (STAR), and thereby ovarian steroidogenesis. The functionality of STAR is associated with the cAMP/PKA-dependent pathways. In vitro, HIF1α is required for basal and cAMP-induced STAR expression, under ambient and reduced oxygen (O

Identifiants

DOI: 10.1016/j.ygcen.2021.113923 PMID: 34606743
pubmed: 34606743
pii: S0016-6480(21)00216-1
doi: 10.1016/j.ygcen.2021.113923
pii:
doi:

Substances chimiques

Creb1 protein, mouse 0
Cyclic AMP Response Element-Binding Protein 0
Hif1a protein, mouse 0
Hypoxia-Inducible Factor 1, alpha Subunit 0
Phosphoproteins 0
Proto-Oncogene Proteins c-jun 0
steroidogenic acute regulatory protein 0
CREB-Binding Protein EC 2.3.1.48
Crebbp protein, mouse EC 2.3.1.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113923

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Bettina Lanfranchi (B)

Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland.

Ricardo Fernandez Rubia (RF)

Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland. Electronic address: ricardo.fernandezrubia@uzh.ch.

Max Gassmann (M)

Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address: maxg@access.uzh.ch.

Gerhard Schuler (G)

Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University, Giessen, Germany. Electronic address: Gerhard.Schuler@vetmed.uni-giessen.de.

Mariusz P Kowalewski (MP)

Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland. Electronic address: kowalewski@vetanat.uzh.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBP-p300 › Protéine CBP › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules de la granulosa › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Transcriptional regulation of HIF1α-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines proto-oncogènes c-jun › Transcriptional regulation of HIF1α-mediated...