Association of mold levels in urban children's homes with difficult-to-control asthma.
APIC
Mucor
US cities
air-conditioner
child
mold
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
20
04
2021
revised:
17
06
2021
accepted:
14
07
2021
pubmed:
5
10
2021
medline:
13
4
2022
entrez:
4
10
2021
Statut:
ppublish
Résumé
Mold sensitization and exposure are associated with asthma severity, but the specific species that contribute to difficult-to-control (DTC) asthma are unknown. We sought to determine the association between overall and specific mold levels in the homes of urban children and DTC asthma. The Asthma Phenotypes in the Inner-City study recruited participants, aged 6 to 17 years, from 8 US cities and classified each participant as having either DTC asthma or easy-to-control (ETC) asthma on the basis of treatment step level. Dust samples had been collected in each participant's home (n = 485), and any dust remaining (n = 265 samples), after other analyses, was frozen at -20 Frozen-dust samples were available from 54% of homes of children with DTC (139 of 253) and ETC asthma (126 of 232). Only the average concentration of the mold Mucor was significantly (P < .001) greater in homes of children with DTC asthma. In homes with window air-conditioning units, the Mucor concentration contributed about a 22% increase (1.6 odds ratio; 95% CI, 1.2-2.2) in the ability to discriminate between cases of DTC and ETC asthma. Mucor levels in the homes of urban youth were a predictor of DTC asthma, and these higher Mucor levels were more likely in homes with a window air-conditioner.
Sections du résumé
BACKGROUND
Mold sensitization and exposure are associated with asthma severity, but the specific species that contribute to difficult-to-control (DTC) asthma are unknown.
OBJECTIVE
We sought to determine the association between overall and specific mold levels in the homes of urban children and DTC asthma.
METHODS
The Asthma Phenotypes in the Inner-City study recruited participants, aged 6 to 17 years, from 8 US cities and classified each participant as having either DTC asthma or easy-to-control (ETC) asthma on the basis of treatment step level. Dust samples had been collected in each participant's home (n = 485), and any dust remaining (n = 265 samples), after other analyses, was frozen at -20
RESULTS
Frozen-dust samples were available from 54% of homes of children with DTC (139 of 253) and ETC asthma (126 of 232). Only the average concentration of the mold Mucor was significantly (P < .001) greater in homes of children with DTC asthma. In homes with window air-conditioning units, the Mucor concentration contributed about a 22% increase (1.6 odds ratio; 95% CI, 1.2-2.2) in the ability to discriminate between cases of DTC and ETC asthma.
CONCLUSIONS
Mucor levels in the homes of urban youth were a predictor of DTC asthma, and these higher Mucor levels were more likely in homes with a window air-conditioner.
Identifiants
pubmed: 34606833
pii: S0091-6749(21)01454-8
doi: 10.1016/j.jaci.2021.07.047
pmc: PMC8975947
mid: NIHMS1745364
pii:
doi:
Substances chimiques
Allergens
0
Dust
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1481-1485Subventions
Organisme : NIAID NIH HHS
ID : HHSN272200900052C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201000052I
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI114271
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI160040
Pays : United States
Informations de copyright
Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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