Monoclonal antibodies for the treatment of COVID-19 patients: An umbrella to overcome the storm?
COVID-19
Monoclonal antibodies
Pneumonia
SARS-CoV-2
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
20
07
2021
revised:
21
09
2021
accepted:
24
09
2021
pubmed:
5
10
2021
medline:
15
1
2022
entrez:
4
10
2021
Statut:
ppublish
Résumé
The world is facing up the most considerable vaccination effort in history to end the Coronavirus disease 2019 (COVID-19) pandemic. Several monoclonal antibodies (mAbs) direct against the Receptor binding domain of the S protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) received an Emergency Use Authorization for outpatient management of mild to moderate manifestation from COVID-19. MAbs could prevent the transmission SARS-CoV-2 infection and protect individuals from progression to severe disease. Under the pressure of different treatment strategies, SARS-CoV-2 has been demonstrated to select for different sets of mutations named "variants" that could impair the effectiveness of mAbs by modifying target epitopes. We provide an overview of both completed and unpublished, or ongoing clinical trials of mAbs used and review state of art in order to describe clinical options, possible indications, and the place in therapy for these agents in the treatment of COVID-19 with a particular focus on anti-spike agents. Then, we reassume the current evidence on mutations of the SARS-CoV-2 that might confer resistance to neutralization by multiple mAbs.
Identifiants
pubmed: 34607231
pii: S1567-5769(21)00836-5
doi: 10.1016/j.intimp.2021.108200
pmc: PMC8479899
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108200Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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