The association between markers of inflammation and retinal microvascular parameters: A systematic review and meta-analysis.

Arterioles Biomarkers Humans Inflammation Microcirculation Retinal Vessels / diagnostic imaging
Fractal dimension Inflammation Microcirculation Retinal microvascular parameters Retinal vascular caliber Tortuosity

Journal

Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543

Informations de publication

Date de publication:
11 2021
Historique:
received: 18 07 2021
revised: 03 09 2021
accepted: 21 09 2021
pubmed: 5 10 2021
medline: 30 11 2021
entrez: 4 10 2021
Statut: ppublish

Résumé

Adverse changes to the microcirculation play an important role in the pathogenesis of cardiovascular disease (CVD), and inflammation is a key causal mechanism. We investigated the relationship between inflammatory markers and retinal microvascular parameters. Studies up to April 2021 were identified in Medline, Embase and PubMed with the following terms: retinal microvascular parameters, inflammatory markers, and observational studies. Correlation coefficients of inflammatory markers and retinal vascular caliber were pooled using the random-effects model. Of 4783 studies identified, 36 met the inclusion criteria (general population 26, patients with diseases 10). C-reactive protein (CRP) and white blood cell count (WBC) were most frequently reported. We conducted meta-analysis with 12 CRP studies (22422 participants) and six WBC studies (15209 participants), and also performed a narrative review of all studies. There was consistent evidence of a modest association between CRP and venular caliber (r = 0.09, 95%CI 0.05 to 0.12), but little evidence of an association between CRP with retinal arteriolar caliber (r = 0.00, 95%CI -0.02 to 0.02). Similarly, WBC had stronger associations with venular (r = 0.18, 95%CI 0.05 to 0.31) than arteriolar caliber (r = 0.05, 95%CI 0.01 to 0.09). Narrative review of other inflammatory markers showed consistent findings. There was little evidence of associations between inflammation markers and other microvascular parameters, fractal dimension and tortuosity. There was more evidence for an association of inflammation with retinal venular than with arterial caliber. The findings suggest a potential druggable mechanism contributing to microvascular damage that has been relatively overlooked in CVD pathogenesis and treatment.

Sections du résumé

BACKGROUND AND AIMS
Adverse changes to the microcirculation play an important role in the pathogenesis of cardiovascular disease (CVD), and inflammation is a key causal mechanism. We investigated the relationship between inflammatory markers and retinal microvascular parameters.
METHODS
Studies up to April 2021 were identified in Medline, Embase and PubMed with the following terms: retinal microvascular parameters, inflammatory markers, and observational studies. Correlation coefficients of inflammatory markers and retinal vascular caliber were pooled using the random-effects model.
RESULTS
Of 4783 studies identified, 36 met the inclusion criteria (general population 26, patients with diseases 10). C-reactive protein (CRP) and white blood cell count (WBC) were most frequently reported. We conducted meta-analysis with 12 CRP studies (22422 participants) and six WBC studies (15209 participants), and also performed a narrative review of all studies. There was consistent evidence of a modest association between CRP and venular caliber (r = 0.09, 95%CI 0.05 to 0.12), but little evidence of an association between CRP with retinal arteriolar caliber (r = 0.00, 95%CI -0.02 to 0.02). Similarly, WBC had stronger associations with venular (r = 0.18, 95%CI 0.05 to 0.31) than arteriolar caliber (r = 0.05, 95%CI 0.01 to 0.09). Narrative review of other inflammatory markers showed consistent findings. There was little evidence of associations between inflammation markers and other microvascular parameters, fractal dimension and tortuosity.
CONCLUSIONS
There was more evidence for an association of inflammation with retinal venular than with arterial caliber. The findings suggest a potential druggable mechanism contributing to microvascular damage that has been relatively overlooked in CVD pathogenesis and treatment.

Identifiants

DOI: 10.1016/j.atherosclerosis.2021.09.025 PMID: 34607278
pubmed: 34607278
pii: S0021-9150(21)01365-4
doi: 10.1016/j.atherosclerosis.2021.09.025
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-22

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Mengjiao Liu (M)

School of Public Health, Nanchang University, Jiangxi, China; Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Jiangxi, China; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.

Claire Lovern (C)

The Gelre Hospitals, Apeldoorn, Netherlands.

Kate Lycett (K)

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; The Deakin Child Study Centre, School of Psychology, Deakin University, VIC, Australia.

Mingguang He (M)

Department of Ophthalmic Epidemiology, Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Melissa Wake (M)

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Paediatrics, Melbourne University, Parkville, VIC, Australia.

Tien Yin Wong (TY)

Department of Ophthalmic Epidemiology, Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia; Singapore Eye Research Institute, Singapore National Eye Center, Singapore.

David P Burgner (DP)

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Paediatrics, Melbourne University, Parkville, VIC, Australia; Department of Paediatrics, Monash University, Clayton, VIC, Australia. Electronic address: david.burgner@mcri.edu.au.

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Classifications MeSH

questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Artérioles › The association between markers of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The association between markers of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The association between markers of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The association between markers of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › The association between markers of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Vaisseaux rétiniens › The association between markers of...