Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
Animals
Basic Helix-Loop-Helix Transcription Factors
/ antagonists & inhibitors
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ antagonists & inhibitors
Carboxylic Ester Hydrolases
/ antagonists & inhibitors
Fasting
/ physiology
Forkhead Transcription Factors
/ metabolism
Gene Expression Regulation
/ genetics
Lipase
/ genetics
Lipolysis
/ physiology
Oxidative Stress
/ physiology
Signal Transduction
/ physiology
Transcription Factors
/ metabolism
Transcription, Genetic
/ genetics
Transcriptional Activation
/ physiology
FOXO/DAF-16
TFEB/HLH-30
fasting
fat
oxidative stress
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 10 2021
12 10 2021
Historique:
accepted:
02
08
2021
entrez:
5
10
2021
pubmed:
6
10
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Plasticity in multicellular organisms involves signaling pathways converting contexts-either natural environmental challenges or laboratory perturbations-into context-specific changes in gene expression. Congruently, the interactions between the signaling molecules and transcription factors (TF) regulating these responses are also context specific. However, when a target gene responds across contexts, the upstream TF identified in one context is often inferred to regulate it across contexts. Reconciling these stable TF-target gene pair inferences with the context-specific nature of homeostatic responses is therefore needed. The induction of the
Identifiants
pubmed: 34607947
pii: 2104832118
doi: 10.1073/pnas.2104832118
pmc: PMC8521664
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Caenorhabditis elegans Proteins
0
Forkhead Transcription Factors
0
HLH-30 protein, C elegans
0
MXL-3 protein, C elegans
0
Transcription Factors
0
daf-16 protein, C elegans
0
heat shock factor-1, C elegans
0
Carboxylic Ester Hydrolases
EC 3.1.1.-
lipl-3 protein, C elegans
EC 3.1.1.-
LIPL-4 protein, C elegans
EC 3.1.1.3
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : K99 DK087928
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK087928
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025616
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Nat Cell Biol. 2013 Jun;15(6):668-76
pubmed: 23604316
Curr Biol. 2001 Dec 11;11(24):1975-80
pubmed: 11747825
Autophagy. 2017 Mar 4;13(3):464-472
pubmed: 28055300
EMBO J. 2018 Jun 1;37(11):
pubmed: 29764979
Science. 2003 May 16;300(5622):1142-5
pubmed: 12750521
Yale J Biol Med. 2019 Sep 20;92(3):435-452
pubmed: 31543707
PLoS Genet. 2010 Feb 19;6(2):e1000848
pubmed: 20174564
Genes Dev. 2016 Feb 1;30(3):307-20
pubmed: 26833730
Science. 2015 Dec 11;350(6266):1375-1378
pubmed: 26586189
Curr Biol. 2006 Apr 18;16(8):780-5
pubmed: 16631585
Elife. 2021 May 12;10:
pubmed: 33978570
Genetics. 2008 Feb;178(2):903-18
pubmed: 18245330
Cell Metab. 2012 May 2;15(5):713-24
pubmed: 22560223
PLoS Genet. 2015 Dec 11;11(12):e1005731
pubmed: 26656736
Sci Signal. 2012 Jun 12;5(228):ra42
pubmed: 22692423
Elife. 2020 Jun 02;9:
pubmed: 32482227
Autophagy. 2016;12(2):261-72
pubmed: 26671266
J Biol Chem. 2005 Nov 25;280(47):39505-9
pubmed: 16183647
Nat Commun. 2020 Oct 2;11(1):4627
pubmed: 33009389
Genes Dev. 2002 May 15;16(10):1167-81
pubmed: 12023297
Aging Cell. 2013 Oct;12(5):814-22
pubmed: 23734734
Genes Dev. 2013 Feb 15;27(4):429-40
pubmed: 23392608
Aging Cell. 2018 Jun;17(3):e12743
pubmed: 29508513
EMBO J. 2012 Mar 7;31(5):1095-108
pubmed: 22343943
Genetics. 1998 Feb;148(2):703-17
pubmed: 9504918
Genetics. 2015 Oct;201(2):613-29
pubmed: 26219299
Autophagy. 2012 Jun;8(6):903-14
pubmed: 22576015
Methods. 2014 Aug 1;68(3):492-9
pubmed: 24784529
Genes Dev. 2009 Feb 15;23(4):496-511
pubmed: 19240135
Cell Rep. 2014 Oct 9;9(1):349-365
pubmed: 25263561
Aging Cell. 2013 Dec;12(6):1073-81
pubmed: 23879233
Methods Mol Biol. 2018;1787:129-146
pubmed: 29736715
Cell. 2017 Mar 9;168(6):960-976
pubmed: 28283069
Nature. 1997 Oct 30;389(6654):994-9
pubmed: 9353126
Arch Toxicol. 2021 Jun;95(6):1943-1970
pubmed: 34003342
J Cell Biol. 2015 Aug 3;210(3):435-50
pubmed: 26240184
PLoS Genet. 2018 Mar 9;14(3):e1007268
pubmed: 29522556
Elife. 2015 Aug 24;4:
pubmed: 26196144
PLoS Genet. 2016 Feb 10;12(2):e1005788
pubmed: 26862916
EMBO J. 2021 Feb 1;40(3):e105793
pubmed: 33314217
Cell. 2015 Oct 8;163(2):340-53
pubmed: 26451484
Nat Commun. 2016 Mar 22;7:10944
pubmed: 27001890
Nat Cell Biol. 2014 Dec;16(12):1168-1179
pubmed: 25419847
J Cell Biol. 2017 Mar 6;216(3):723-741
pubmed: 28183717
Nat Commun. 2018 Oct 23;9(1):4400
pubmed: 30353013
Cell Rep. 2015 May 19;11(7):1123-33
pubmed: 25959815
Science. 2008 Nov 7;322(5903):957-60
pubmed: 18988854
Science. 2013 Jul 19;341(6143):1238303
pubmed: 23869022
Curr Biol. 2011 Sep 27;21(18):1507-14
pubmed: 21906946
Cold Spring Harb Symp Quant Biol. 2011;76:113-20
pubmed: 22123849
Nat Commun. 2013;4:2267
pubmed: 23925298
Mol Syst Biol. 2010 Aug 10;6:399
pubmed: 20706209
Aging Cell. 2013 Feb;12(1):112-20
pubmed: 23107491
WormBook. 2015 Jun 09;:1-49
pubmed: 26069085
Cell. 2008 Mar 21;132(6):1025-38
pubmed: 18358814
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13496-501
pubmed: 16157872
Cell Metab. 2013 Jan 8;17(1):85-100
pubmed: 23312285
Aging Cell. 2014 Oct;13(5):869-78
pubmed: 25040785