Adequate immune response after SARS-CoV-2 infection and single dose vaccination despite rapid heart transplantation.
COVID-19
Immune response
Immune suppression
Orthotopic heart transplantation
SARS-CoV-2
Vaccination
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
03
09
2021
received:
18
06
2021
accepted:
13
09
2021
pubmed:
6
10
2021
medline:
5
1
2022
entrez:
5
10
2021
Statut:
ppublish
Résumé
Adequate immune response to vaccination remains a challenge in patients after solid organ transplantation. We report a case of a 61-year-old male patient who received a left ventricular assist device as a bridge to transplant therapy. Three months before transplantation, he suffered mild SARS-CoV-2 infection and was successfully discharged thereafter. Eight days before his successful heart transplantation, he received mRNA BNT 162b2 vaccination. Immediately after transplantation, we detected sufficient rise of nucleocapsid and spike antibodies despite immune suppression therapy. We suspect potential booster effects of the previous SARS-CoV-2 infection giving rise to adequate immune response following single vaccination.
Identifiants
pubmed: 34608773
doi: 10.1002/ehf2.13635
pmc: PMC8652618
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
5568-5571Informations de copyright
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
J Heart Lung Transplant. 2021 Aug;40(8):759-762
pubmed: 34034958
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Nature. 2020 Oct;586(7830):589-593
pubmed: 32785213
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Eur J Heart Fail. 2021 Sep;23(9):1555-1559
pubmed: 33963635
BMC Infect Dis. 2021 Jan 20;21(1):89
pubmed: 33472599
ESC Heart Fail. 2021 Dec;8(6):5568-5571
pubmed: 34608773
Transplantation. 2021 Oct 1;105(10):2170-2174
pubmed: 33859151
Lancet. 2021 Mar 27;397(10280):1178-1181
pubmed: 33640037
JAMA. 2021 May 4;325(17):1784-1786
pubmed: 33720292
Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1063-1071
pubmed: 33534090
JAMA. 2021 Jun 1;325(21):2204-2206
pubmed: 33950155