Cell survival after DNA damage in the comet assay.

Antineoplastic Agents, Alkylating / administration & dosage Apoptosis / drug effects Cell Line Cell Proliferation / drug effects Cell Survival / drug effects Comet Assay DNA Damage / drug effects DNA Repair / drug effects Dose-Response Relationship, Drug Etoposide / administration & dosage Humans Hydrogen Peroxide / administration & dosage Methyl Methanesulfonate / administration & dosage Oxidants / administration & dosage Time Factors Topoisomerase II Inhibitors / administration & dosage
Cell death and comet assay DNA damage DNA repair

Journal

Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615

Informations de publication

Date de publication:
12 2021
Historique:
received: 31 07 2021
accepted: 16 09 2021
pubmed: 6 10 2021
medline: 11 2 2022
entrez: 5 10 2021
Statut: ppublish

Résumé

The comet assay is widely used in basic research, genotoxicity testing, and human biomonitoring. However, interpretation of the comet assay data might benefit from a better understanding of the future fate of a cell with DNA damage. DNA damage is in principle repairable, or if extensive, can lead to cell death. Here, we have correlated the maximally induced DNA damage with three test substances in TK6 cells with the survival of the cells. For this, we selected hydrogen peroxide (H

Identifiants

DOI: 10.1007/s00204-021-03164-3 PMID: 34609522 PMC: PMC8536587
pubmed: 34609522
doi: 10.1007/s00204-021-03164-3
pii: 10.1007/s00204-021-03164-3
pmc: PMC8536587
doi:

Substances chimiques

Antineoplastic Agents, Alkylating 0
Oxidants 0
Topoisomerase II Inhibitors 0
Etoposide 6PLQ3CP4P3
Methyl Methanesulfonate AT5C31J09G
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3803-3813

Informations de copyright

© 2021. The Author(s).

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Auteurs

Ezgi Eyluel Bankoglu (EE)

Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Straße 9, 97078, Wuerzburg, Germany.
ORCID: 0000-0001-7488-6228

Carolin Schuele (C)

Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Straße 9, 97078, Wuerzburg, Germany.

Helga Stopper (H)

Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Straße 9, 97078, Wuerzburg, Germany. stopper@toxi.uni-wuerzburg.de.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Agents alcoylants › Antinéoplasiques alcoylants › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Techniques d'investigation › Tests de toxicité › Tests de mutagénicité › Test des comètes › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › Étoposide › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Acides alcanesulfoniques › Alcanesulfonates › Méthanesulfonates › Méthanesulfonate de méthyle › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Oxydants › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Cell survival after DNA damage in the comet assay.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › Inhibiteurs de la topoisomérase-II › Cell survival after DNA damage in the comet assay.