Impact of an allied health prehabilitation service for haematologic patients receiving high-dose chemotherapy in a large cancer centre.
Allied health
Autologous stem cell transplant
High-dose chemotherapy
Implementation
Prehabilitation
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
21
04
2021
accepted:
29
09
2021
pubmed:
6
10
2021
medline:
7
1
2022
entrez:
5
10
2021
Statut:
ppublish
Résumé
Evaluate the impact of a new multidisciplinary allied health prehabilitation service in haematologic cancer patients receiving high-dose chemotherapy with autologous stem cell transplant (AuSCT). In a tertiary cancer centre, 12 months of prospectively collected data was retrospectively analysed. Patients were referred to an allied health service for individualised exercise prescription, nutrition intervention and, if indicated through screening, psychological intervention. Impact and operational success were investigated using the RE-AIM framework: patient uptake of the service and sample representativeness (reach); effectiveness in terms of changes in outcomes from initial to pre-transplant assessment; adoption of the service by key stakeholders; fidelity of the prescribed exercise program (implementation); and the extent to which the new service had become routine practice (maintenance). One hundred and eighty-three patients were referred to the AuSCT service over 12 months, of whom 133 (73%) were referred into the prehabilitation service, 128 (96%) were eligible and 116 (91%) participated. Patients were representative of Australian AuSCT patients. Eighty-nine patients reached pre-transplant assessment by data censoring; 6-min walk distance (n = 45/89, 51%) improved a mean (95% CI) of 39.9 m (18.8 to 61.0, p = < 0.005) from baseline. Fidelity of exercise prescription was moderate with 72% of eligible patients receiving the intended exercise interventions. The referral trend over time (maintenance) was high after the initiation period. The prehabilitation service was well adopted by clinicians. Clinically relevant improvements in outcomes were demonstrated. Recommendations, including development of well-integrated discipline-specific assessment intervention and measurement protocols, are highlighted for service improvement. Prehabilitation should be routinely considered to support patients undergoing AuSCT.
Identifiants
pubmed: 34609585
doi: 10.1007/s00520-021-06607-w
pii: 10.1007/s00520-021-06607-w
pmc: PMC8491182
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1852Informations de copyright
© 2021. Crown.
Références
Soerjomataram I, Lortet-Tieulent J, Parkin DM, Ferlay J, Mathers C, Forman D et al (2012) Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions. Lancet 380(9856):1840–1850
doi: 10.1016/S0140-6736(12)60919-2
Carli F, Zavorsky GS (2005) Optimizing functional exercise capacity in the elderly surgical population. Curr Opin Clin Nutr Metab Care 8(1):23–32
doi: 10.1097/00075197-200501000-00005
Chakraborty R, Hamilton BK, Hashmi SK, Kumar SK, Majhail NS (2018) Health-related quality of life after autologous stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 24(8):1546–1553
doi: 10.1016/j.bbmt.2018.03.027
Silver JK, Baima J (2013) Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil 92(8):715–727
doi: 10.1097/PHM.0b013e31829b4afe
Macmillan Cancer Support. Prehabilitation for people with cancer 2017
Gillis C, Li C, Lee L, Awasthi R, Augustin B, Gamsa A et al (2014) Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology 121(5):937–947
doi: 10.1097/ALN.0000000000000393
West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ et al (2015) Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth 114(2):244–251
doi: 10.1093/bja/aeu318
Wood WA, Phillips B, Smith-Ryan AE, Wilson D, Deal AM, Bailey C et al (2016) Personalized home-based interval exercise training may improve cardiorespiratory fitness in cancer patients preparing to undergo hematopoietic cell transplantation. Bone Marrow Transplant 51(7):967–972
doi: 10.1038/bmt.2016.73
van Haren I, Staal JB, Potting CM, Atsma F, Hoogeboom TJ, Blijlevens NMA et al (2018) Physical exercise prior to hematopoietic stem cell transplantation: a feasibility study. Physiother Theory Pract 34(10):747–756
doi: 10.1080/09593985.2018.1423655
Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B (2003) Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs 26(5):410–419
doi: 10.1097/00002820-200310000-00012
Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F et al (2017) ESPEN guidelines on nutrition in cancer patients. Clin Nutr 36(1):11–48
doi: 10.1016/j.clnu.2016.07.015
Glasgow RE, Vogt TM, Boles SM (1999) Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health 89(9):1322–1327
doi: 10.2105/AJPH.89.9.1322
Glasgow RE, Harden SM, Gaglio B, Rabin B, Smith ML, Porter GC et al (2019) RE-AIM Planning and evaluation framework: adapting to new science and practice with a 20-Year review. Front Public Health 7:64
doi: 10.3389/fpubh.2019.00064
Gaglio B, Shoup JA, Glasgow RE (2013) The RE-AIM framework: a systematic review of use over time. Am J Public Health 103(6):e38-46
doi: 10.2105/AJPH.2013.301299
Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D et al (2014) Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ 348:g1687
doi: 10.1136/bmj.g1687
Abernethy AP, Shelby-James T, Fazekas BS, Woods D, Currow DC (2005) The Australia-modified Karnofsky Performance Status (AKPS) scale: a revised scale for contemporary palliative care clinical practice [ISRCTN81117481]. BMC Palliat Care 4:7
doi: 10.1186/1472-684X-4-7
Kroenke K, Spitzer RL, Williams JB, Lowe B (2009) An ultra-brief screening scale for anxiety and depression: the PHQ-4. Psychosomatics 50(6):613–621
Hayes SC, Newton RU, Spence RR, Galvao DA (2019) The exercise and sports science Australia position statement: exercise medicine in cancer management. J Sci Med Sport 22(11):1175–1199
doi: 10.1016/j.jsams.2019.05.003
Department of Primary Industries and Energy and Department of Human Services and Health (1994) Rural, remote and metropolitan areas classification (RRMA). Commonwealth of Australia, Canberra
Borrelli B (2011) The assessment, monitoring, and enhancement of treatment fidelity in public health clinical trials. J Public Health Dent 71(Suppl 1):S52-63
doi: 10.1111/j.1752-7325.2011.00233.x
Brewster AL, Curry LA, Cherlin EJ, Talbert-Slagle K, Horwitz LI, Bradley EH (2015) Integrating new practices: a qualitative study of how hospital innovations become routine. Implement Sci 10:168
doi: 10.1186/s13012-015-0357-3
Holland AE, Spruit MA, Troosters T, Puhan MA, Pepin V, Saey D et al (2014) An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 44(6):1428–1446
doi: 10.1183/09031936.00150314
Schmidt K, Vogt L, Thiel C, Jager E, Banzer W (2013) Validity of the six-minute walk test in cancer patients. Int J Sports Med 34(7):631–636
doi: 10.1055/s-0032-1323746
Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S (1985) Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil 66(2):69–74
pubmed: 3970660
Trutschnigg B, Kilgour RD, Reinglas J, Rosenthall L, Hornby L, Morais JA et al (2008) Precision and reliability of strength (Jamar vs. Biodex handgrip) and body composition (dual-energy X-ray absorptiometry vs. bioimpedance analysis) measurements in advanced cancer patients. Appl Physiol Nutr Metab. 33(6):1232–9
doi: 10.1139/H08-122
Jones CJ, Rikli RE, Beam WC (1999) A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport 70(2):113–119
doi: 10.1080/02701367.1999.10608028
Bauer J, Capra S, Ferguson M (2002) Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer. Eur J Clin Nutr 56(8):779–785
doi: 10.1038/sj.ejcn.1601412
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376
doi: 10.1093/jnci/85.5.365
Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE et al (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35(8):1381–1395
doi: 10.1249/01.MSS.0000078924.61453.FB
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42(2):377–381
doi: 10.1016/j.jbi.2008.08.010
Perneger TV (1998) What’s wrong with Bonferroni adjustments. BMJ 316(7139):1236–1238
doi: 10.1136/bmj.316.7139.1236
ABMTRR (2019) Australasian Bone Marrow Transplant Recipient Registry: Annual Data Summary 2018. Australasian Bone Marrow Transplant Recipient Registry, Darlinghurst
The Department of Health. Rural, Remote and Metropolitan Areas Classification (RRMA) 2008. Available from: https://www1.health.gov.au/internet/publications/publishing.nsf/Content/work-res-ruraud-toc~work-res-ruraud-lis~work-res-ruraud-lis-e . Accessed 10 Sep 2021
SimpleSet. SimpleSet 2009. Available from: https://simpleset.net .
Moore J, Merchant Z, Rowlinson K, McEwan K, Evison M, Faulkner G et al (2020) Implementing a system-wide cancer prehabilitation programme: the journey of Greater Manchester's 'Prehab4cancer'. Eur J Surg Oncol
Schmitz KH, Campbell AM, Stuiver MM, Pinto BM, Schwartz AL, Morris GS et al (2019) Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA Cancer J Clin 69(6):468–484
doi: 10.3322/caac.21579
Granger CL, Holland AE, Gordon IR, Denehy L (2015) Minimal important difference of the 6-minute walk distance in lung cancer. Chron Respir Dis 12(2):146–154
doi: 10.1177/1479972315575715
Gibbons WJ, Fruchter N, Sloan S, Levy RD (2001) Reference values for a multiple repetition 6-minute walk test in healthy adults older than 20 years. J Cardiopulm Rehabil 21(2):87–93
doi: 10.1097/00008483-200103000-00005
Bauer MS, Damschroder L, Hagedorn H, Smith J, Kilbourne AM (2015) An introduction to implementation science for the non-specialist. BMC Psychol 3:32
doi: 10.1186/s40359-015-0089-9
Santa Mina D, Au D, Auger LE, Alibhai SMH, Matthew AG, Sabiston CM et al (2019) Development, implementation, and effects of a cancer center’s exercise-oncology program. Cancer 125(19):3437–3447
doi: 10.1002/cncr.32297
Poltawski L, Norris M, Dean S (2014) Intervention fidelity: developing an experience-based model for rehabilitation research. J Rehabil Med 46(7):609–615
doi: 10.2340/16501977-1848
Taylor KL, Weston M, Batterham AM (2015) Evaluating intervention fidelity: an example from a high-intensity interval training study. PLoS ONE 10(4):e0125166
doi: 10.1371/journal.pone.0125166
Waterland JL, Ismail H, Amin B, Granger CL, Denehy L, Riedel B (2020) Patient acceptance of prehabilitation for major surgery: an exploratory survey. Support Care Cancer 29:779–785
doi: 10.1007/s00520-020-05547-1
Steffens D, Delbaere K, Young J, Solomon M, Denehy L (2020) Evidence on technology-driven preoperative exercise interventions: are we there yet? Br J Anaesth. 125:646–649
doi: 10.1016/j.bja.2020.06.050