Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei.
Cerebellum
Interposed nucleus
Thalamus
Trans-synaptic tracing
Ventrolateral nucleus
Journal
Neuroscience bulletin
ISSN: 1995-8218
Titre abrégé: Neurosci Bull
Pays: Singapore
ID NLM: 101256850
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
20
04
2021
accepted:
19
07
2021
pubmed:
6
10
2021
medline:
6
11
2021
entrez:
5
10
2021
Statut:
ppublish
Résumé
The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors. Although the axons of deep cerebellar nuclei are known to project to primary thalamic nuclei, macroscopic investigation of the characteristics of these projections, such as the spatial distribution of recipient zones, is lacking. Here, we studied the output of the cerebellar interposed nucleus (IpN) to the ventrolateral (VL) and centrolateral (CL) thalamic nuclei using electrophysiological recording in vivo and trans-synaptic viral tracing. We found that IpN stimulation induced mono-synaptic evoked potentials (EPs) in the VL but not the CL region. Furthermore, both the EPs induced by the IpN and the innervation of IpN projections displayed substantial heterogeneity across the VL region in three-dimensional space. These findings indicate that the recipient zones of IpN inputs vary between and within thalamic nuclei and may differentially control thalamo-cortical networks.
Identifiants
pubmed: 34609736
doi: 10.1007/s12264-021-00780-y
pii: 10.1007/s12264-021-00780-y
pmc: PMC8566630
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1529-1541Informations de copyright
© 2021. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
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